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12/31/2004 New Route to Parkinson's Found in Cells' 'Garbage Disposal' System
Researchers found in studies with rats that a gene called BAG5 enhances the death of the dopaminergic neurons targeted by Parkinson's and that inhibiting the gene reduces such death.
12/20/2004 New PD Drug Target Identified
Curis, a drug development company, has developed several promising small molecule compounds that promote neuron repair in a preclinical model of Parkinson's disease.
12/16/2004 Avigen's AV201 for Parkinson's Disease Begins Clinical Trials
New Approach Targets Later-Stage Disease
AV201, an experimental gene therapy drug candidate designed to restore and extend the therapeutic effectiveness of levodopa is being tested in a Phase 1/2 trial for people with severe Parkinson's.
12/06/2004 Two-Fisted Assault on Dopamine Transport System May Be Foundation of Parkinson's Disease
Protecting microtubule "highways" may lead to novel therapies, study shows
Researchers have shown that the presence of mutated parkin genes, combined with the toxic effects of the chemical rotenone, results in a cascade of highly toxic free radicals, the destruction of microtubules that transport dopamine to the brain's movement center, and eventual death of the dopamine-producing neuron.
12/04/2004 Antibiotic Rifampicin Shows Promise for Fighting Parkinson's Disease in Laboratory Tests
New research indicates that rifampicin may prevent the formation of protein fibrils associated with neuron death in people with PD.
12/01/2004 Surface Brain Stimulation May Ease Parkinson's Symptoms
Surface brain stimulation may represent an alternative to deep brain stimulation to help ease movement problems caused by PD, according to new research.
11/30/2004 Michael J. Fox Foundation Directs Drug Discovery and Development Effort to Stimulate Advances in Parkinson's
The Foundation has launched a $1.5 million initiative to validate potential drug targets for Parkinson's disease.
11/29/2004 Gene Therapy Shows Promise in Model of Parkinson's Disease
MJFF funded research indicates that viral delivery of a gene associated with Parkinson's may protect neurons from degeneration.
11/26/2004 Many See Hope in Parkinson's Drug Pulled From Testing
Parkinson's patients involved with GDNF clinical trials seek continued treatment after Amgen pulls drug.
11/10/2004 Michael J. Fox Foundation Leads Hunt for Parkinson's Biomarker
"Molecular Fingerprint" Critical to Diagnosis and Development of Treatments to Slow or Stop Disease Progression
MJFF has launched a second research initiative aimed at identifying a biomarker for Parkinson's.
11/08/2004 First Website on Parkinson's Clinical Trials Unveiled
Collaboration between Voluntary Disease Groups, Industry and Government Marks Launch of Website Devoted to Parkinson’s Clinical Research
Advancing Parkinson's Therapies launched a comprehensive Web site with information about Parkinson's clinical trials.
11/02/2004 Passing of Proposition 71 in California Sends Strong Signal to Capitol Hill; Patient Voices Being Heard in California
Californians voted to authorize the state to spend up to $3 billion in stem cell research over the next ten years.
10/27/2004 American Academy of Neurology and American Neurological Association Announce Support for Embryonic and Adult Human Stem Cell Research
Two top neurological associations support government funding for stem cell research.
10/27/2004 AGILECT(R) Improved Parkinson's Disease Symptoms Without Worsening Cognitive and Behavioral Symptoms
Data Presented at Mental Dysfunction in Parkinson's Disease Conference
Data from two studies indicate that Agilect may improve PD symptoms without increasing cognitive and behavioral adverse events.
10/26/2004 Novartis and Orion Pharma Launch First Parkinson's Disease Study to Explore Potential of Delaying Motor Complications With Stalevo(R)
Parkinson's Patients Who Require the Start of Levodopa Therapy May Be Eligible to Participate in This Study
Novartis and Orion's STRIDE-PD study to explore whether Stalevo can delay the onset of motor complications like dyskinesias.
10/25/2004 Exercise Might Protect Against Parkinson's Disease
Research in rats indicates that exercise may help protect the brain cells normally damaged in Parkinson's.
10/22/2004 Researchers Discover Gene Mutations for Parkinson's Disease
Researchers at the National Institute on Aging have discovered a gene, which when mutated, causes Parkinson's in some families.
10/15/2004 Muhammad Ali Center Launches
The information will be used to facilitate the development of new therapies and healthcare services to improve the quality of life for people with PD.
10/12/2004 Positive Trial Results for Rotigotine Patch 'Neupro' in Advanced Parkinson's Disease
SCHWARZ PHARMA's NeuproTM given as adjunctive therapy to people with advanced Parkinson's reduced 'off' time without increasing dyskinesias.
Phase III trial with Neupro TM reports statistically significant and clinically relevant reduction in 'off' time. 99% of patients continue in the open-label extension trial.
09/29/2004 Parkinson's, Epilepsy Linked with Depression
Research suggests that depression may be linked to Parkinson's and epilepsy.
09/28/2004 World Parkinson Congress Launches Web Site for First-Ever Meeting for Researchers, Parkinson's Patients and Caregivers
Information about the World Parkinson Congress is now available at www.worldpdcongress.org.
09/27/2004 Researchers Find Genetic Duplication Causes Familial Parkinson's Disease
Results from a recent study indicate that the amount of alpha-synuclein gene present in the human brain may influence the course of PD.
08/30/2004 FDA Grants Final Approval for SCHWARZ PHARMA's Parcopa
The Food and Drug Administration has approved an orally disolvable Parkinson's medication.
08/17/2004 WE MOVE Advances Health Literacy for People Living With Parkinson's Disease
WE MOVE launched a multi-tiered educational program to advance health literacy for people living with Parkinson's disease.
06/22/2004 Study Says DBS Has Little Impact on Mental Functioning or Mood
06/22/2004 Potential Biological Basis for Depression in PD
Parkinson's patients with a high level of homocysteine are more likely to be depressed.
06/14/2004 Vaccine Therapy Produces Positive Results in Early Animal Study
04/28/2004 Parkinson's Disease Cell Loss Starts Years Before Diagnosis
Medical News Today reports that new research indicates the loss of brain cells that leads to <i>Medical News Today</i> reports that new research indicates the loss of brain cells that leads to Parkinson's disease starts an estimated 13 years before the diagnosis. disease starts an estimated 13 years before the diagnosis.
04/21/2004 Parkinson's Patient Survey Available Online
Bertek Pharmaceuticals is seeking help in gathering information about "off" episodes, a devastating symptom of Parkinson's disease. Patients' Opinion Poll, a market research company specializing in health care research, is conducting a nationwide survey about "off" episodes. The survey is available online.
04/21/2004 FDA Approves New Parkinson's Drug
The Food and Drug Administration has approved a new drug to treat Parkinson's patients who develop periods of immobility.
02/23/2004 NIH Initiates Phase II Clinical Trial to Test New Parkinson's Drug
Guilford Pharmaceuticals Inc.
(Nasdaq: GLFD) announced today that the National Institutes of Health (NIH)
has initiated a Phase II clinical trial to test the Company's neuroimmunophilin ligand, GPI 1485, as part of a comprehensive program investigating novel neuroprotective therapies for Parkinson's disease.
01/05/2004 New Jersey becomes second state to allow stem cell research
New Jersey became the second state to allow stem cell research on Sunday as Gov. James E. McGreevey signed a law he said will "move the frontiers of science forward."
11/03/2003 Participants needed for Clinical Trials
The National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) needs volunteers in large national study to find treatments to stop the progression or worsening of Parkinson's disease.
10/30/2003 Study: Extra copies of gene may cause Parkinson's
Certain patients with Parkinson's disease carry extra copies of a gene that clogs their brains with excess proteins -- a finding that may lead to better treatments and perhaps a way to stop the deadly disease, scientists recently said.
09/10/2003 Sometimes the Labels Lie
Consumerlab.com tests various brands of vitamins and herbal supplements and finds some do not deliver what is promised on the labels (New York Times, September 9, 2003)
08/21/2003 Foundation Releases Statement on Gene Therapy as a Treatment for Parkinson's Disease
Response to news of Phase I gene therapy clinical trial currently underway at New York Weill Cornell Medical Center.
08/18/2003 Aspirin May Lower Parkinson's Risk
Study: anti-inflammatories appear to ward off the disease
06/25/2003 FDA Approves New Parkinson's Drug
The United States Food and Drug Administration has approved Stalevo(R) for use in treating Parkinson's disease.
04/11/2003 NINDS Launches Two Large Clinical Trials for Parkinson's Disease
The National Institute of Neurological Disorders and Stroke (NINDS) has launched a trial for deep brain stimulation (DBS) and another to study the impact of two neuroprotective agents.
03/31/2003 Parkinson's Drug Shows Promise
A preliminary trial to test the safety of a drug in people with Parkinson's disease surprised scientists when all five patients showed measurable improvement.
02/10/2003 Scientists replace human stem cell genes
Scientists said on Sunday, February 9 they had, for the first time, genetically manipulated human stem cells -- a first step towards making the body's so-called master cells into a useful tool.
02/05/2003 Sen. Hatch sided with science on stem cells
Legislation sponsored by Hatch and four senators who support abortion rights - Arlen Specter (R., Pa.), Dianne Feinstein (D., Calif.), Edward M. Kennedy (D., Mass.) and Tom Harkin (D., Iowa) - would ban cloning to create human beings, called "reproductive cloning," but would allow it for research, or "therapeutic cloning."
01/16/2003 Scientific Advisory Board Responds to Fetal Tissue Study Results
Our Scientific Advisory Board shares observations on the results of Dr. Warren Olanow's fetal tissue study and his recent report on the issue.
11/18/2002 Preliminary Study Shows High-Dose Coenzyme Q10 Slows Functional Decline in Parkinson's Disease Patients
A national clinical trial with 80 Parkinson's disease patients has shown that high dosages of a naturally occurring compound, coenzyme Q10, slowed by 44 percent the progressive deterioration in function that occurs in the disease. The greatest benefit was seen in everyday activities such as feeding, dressing, bathing and walking.
05/22/2002 Fox and Ali Speak Out for PD Research
Michael J. Fox and Foundation Board Member Lonnie Ali testified before a Senate subcommittee on the need to increase federal spending on PD research.
05/22/2002 Michael J. Fox's Testimony at Hearing on Parkinson's Disease Research
United States Senate Appropriations Subcommittee
05/22/2002 Michael J. Fox Testifies on Parkinson's Research
05/14/2002 PD ''Cluster'' Sparks Researchers' Interest
Four people who worked at a Canadian TV studio in the 1970s--including Michael J. Fox--have contracted Parkinson's. Researchers have begun to focus on whether this "cluster" may provide clues to PD's cause.
03/01/2002 ''Cluster'' Story Raises Questions About Cause of Parkinson's Disease
The Foundation releases a policy statement on the PD "Canadian Cluster"
08/09/2001 Bush Unveils Tentative Policy on Embryonic Stem Cell Research
The Foundation releases a policy statement in response to President Bush's new policy on federal funding of embryonic stem cell research
01/01/2000 Mediterranean Diet May Prevent Mental Decline
Eating a Mediterranean diet appears to lower risk for mental decline, and may help prevent Alzheimer’s in people with existing memory problems, new research suggests.
01/01/2000 University of Arkansas at Little Rock Study Targets Root of Parkinson’s Disease
University of Arkansas at Little Rock chemistry professor Jerry Darsey and doctoral student Sushma Thotakura are leading a one-year study examining Parkinson’s disease at its most fundamental level with a grant from The Michael J. Fox Foundation for Parkinson’s Research.
01/01/2000 Rare Sharing of Data Leads to Progress on Alzheimer’s
