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  • African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
    2024
    OPEN
    Title: African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
    Author(s): Pilar Álvarez Jerez, Peter Wild Crea, Daniel M. Ramos, Emil K. Gustavsson, Mandy Radefeldt, Andrey Damianov, Mary B. Makarious, Oluwadamilola O. Ojo, Kimberley J. Billingsley, Laksh Malik, Kensuke Daida, Sarah Bromberek, Fangle Hu, Zachary Schneider, Aditya Surapaneni, Julia T. Stadler, Mie Rizig, Huw R. Morris, Caroline B. Pantazis, Hampton L. Leonard, Laurel A. Screven, Yue Qi, M. A. Nalls, Sara Bandrés‐Ciga, John Hardy, Henry Houlden, Celeste Eng, Esteban G. Burchard, Linda Kachuri, Chia-Ho Lin, Douglas L. Black, M. A. Nalls, Andrew B. Singleton, Steffen Fischer, Peter Bauer, Xylena Reed, Mina Ryten, Christian Beetz, Michael E. Ward, Njideka Okubadejo, Cornelis Blauwendraat
    Journal Name: Nature Structural & Molecular Biology
    Publisher: Springer Science and Business Media LLC
    Vol: 31
    Issue #: 12
    Start Page: 1955
    End Page: 1963
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by, cc-by
    DOI - Digital Object Identifier: 10.1038/s41594-024-01423-2
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    Citation Count: 0
  • Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson’s Disease
    2024
    OPEN
    Title: Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson’s Disease
    Author(s): Xiaohui Tang, Qian Liang, Tao Li, Yi Ouyang, Zhe Huang, X.-F. Tang, Jiayi Jin, Lijia Yu, Xijin Wang
    Journal Name: Neuropsychiatric Disease and Treatment
    Publisher: Informa UK Limited
    Vol: Volume 20
    Issue #:
    Start Page: 2517
    End Page: 2527
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.2147/ndt.s485339
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    Citation Count: 0
  • Global Perspectives on Returning Genetic Research Results in Parkinson Disease
    2024
    RESTRICTED
    Title: Global Perspectives on Returning Genetic Research Results in Parkinson Disease
    Author(s): Ai Huey Tan, Paula Saffie Awad, Artur Francisco Schumacher Schuh, Shen‐Yang Lim, Harutyun Madoev, Azlina Ahmad, Justin Solle, Claire E. Wegel, Maria Leila Doquenia, Sumit Dey, María Teresa Periñán, Mary B. Makarious, Brian P. Fiske, Huw R. Morris, Alastair J. Noyce, Roy N. Alcalay, Kishore R. Kumar, Christine Klein
    Journal Name: Neurology Genetics
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Vol: 10
    Issue #: 6
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1212/nxg.0000000000200213
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    Citation Count: 0
  • Longitudinal correlation of cerebrospinal fluid GFAP and the progression of cognition decline in different clinical subtypes of Parkinson's disease
    2024
    OPEN
    Title: Longitudinal correlation of cerebrospinal fluid GFAP and the progression of cognition decline in different clinical subtypes of Parkinson's disease
    Author(s): Yumei Liu, Jing Wang, Fangbo Ning, Guojun Wang, Anmu Xie
    Journal Name: Clinical and Translational Science
    Publisher: Wiley
    Vol: 17
    Issue #: 12
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1111/cts.70111
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    Citation Count: 0
  • Opto-Avoidance-Elevated Plus Maze protocol to study positive or negative valence upon optogenetic stimulation in the mouse brain
    2024
    OPEN
    Title: Opto-Avoidance-Elevated Plus Maze protocol to study positive or negative valence upon optogenetic stimulation in the mouse brain
    Author(s): Gian Pietro Serra, François Georges, Åsa Wallén‐Mackenzie
    Journal Name: STAR Protocols
    Publisher: Elsevier BV
    Vol: 5
    Issue #: 4
    Start Page: 103474
    End Page: 103474
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1016/j.xpro.2024.103474
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    Citation Count: 0
  • Structural Basis for the Pathogenicity of Parkin Catalytic Domain Mutants
    2024
    RESTRICTED
    Title: Structural Basis for the Pathogenicity of Parkin Catalytic Domain Mutants
    Author(s): Julian P. Wagner, Véronique Sauvé, Anshu Saran, Kalle Gehring
    Journal Name: Journal of Biological Chemistry
    Publisher: Elsevier BV
    Vol: 301
    Issue #: 1
    Start Page: 108051
    End Page: 108051
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License: cc-by
    DOI - Digital Object Identifier: 10.1016/j.jbc.2024.108051
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    Citation Count: 1
  • MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity
    2024
    OPEN
    Title: MJF-14 proximity ligation assay detects early non-inclusion alpha-synuclein pathology with enhanced specificity and sensitivity
    Author(s): Nanna Møller Jensen, YuHong Fu, Cristine Betzer, Hongyun Li, Sara Elfarrash, Ali H. Shaib, Donatus Krah, Zagorka Vitic, Lasse Reimer, Hjalte Gram, Vladimir L. Buchman, Mark Denham, Silvio O. Rizzoli, Glenda M. Halliday, Poul Henning Jensen
    Journal Name: npj Parkinson's Disease
    Publisher: Springer Science and Business Media LLC
    Vol: 10
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/s41531-024-00841-9
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    Citation Count: 0
  • Seeding activity of skin misfolded tau as a biomarker for tauopathies
    2024
    OPEN
    Title: Seeding activity of skin misfolded tau as a biomarker for tauopathies
    Author(s): Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Syed Zahid Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen‐Quan Zou
    Journal Name: Molecular Neurodegeneration
    Publisher: Springer Science and Business Media LLC
    Vol: 19
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1186/s13024-024-00781-1
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    Citation Count: 0
  • A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
    2024
    OPEN
    Title: A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
    Author(s): Caroline Brown, Snehasish Ghosh, Rachel McAllister, Mukesh Kumar, Gerard Walker, Eric I. Sun, Talat Aman, Aniruddha Panda, Shailesh Kumar, Wenxue Li, Jeff Coleman, Yansheng Liu, James E. Rothman, Moitrayee Bhattacharyya, Kallol Gupta
    Journal Name: Nature Methods
    Publisher: Springer Science and Business Media LLC
    Vol: 22
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by, cc-by
    DOI - Digital Object Identifier: 10.1038/s41592-024-02517-x
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    Citation Count: 0
  • Enhancement and evaluation for deep learning-based classification of volumetric neuroimaging with 3D-to-2D knowledge distillation
    2024
    OPEN
    Title: Enhancement and evaluation for deep learning-based classification of volumetric neuroimaging with 3D-to-2D knowledge distillation
    Author(s): Hyemin Yoon, Do-Young Kang, Sangjin Kim
    Journal Name: Scientific Reports
    Publisher: Springer Science and Business Media LLC
    Vol: 14
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/s41598-024-80938-6
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    Citation Count: 0
  • Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson’s Disease: A Coordinated Analysis
    2024
    RESTRICTED
    Title: Discordance Between Balance Ability and Perception Is Associated With Falls in Parkinson’s Disease: A Coordinated Analysis
    Author(s): Jason K. Longhurst, Andrew Hooyman, Merrill R. Landers, Martina Mancini, Erika Franzén, Breiffni Leavy, Hanna Johansson, Daniel S. Peterson
    Journal Name: Neurorehabilitation and Neural Repair
    Publisher: SAGE Publications
    Vol: 39
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1177/15459683241300456
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    Citation Count: 1
  • Enhanced Parkin-mediated mitophagy mitigates adverse left ventricular remodelling after myocardial infarction: role of PR-364
    2024
    OPEN
    Title: Enhanced Parkin-mediated mitophagy mitigates adverse left ventricular remodelling after myocardial infarction: role of PR-364
    Author(s): Lizhuo Ai, Juliana de Freitas Germano, Chengqun Huang, Marianne Aniag, Savannah Sawaged, Jon Sin, Reetu Thakur, Deepika Rai, Christopher Rainville, David E. Sterner, Yang Song, Honit Piplani, Suresh Kumar, Tauseef R. Butt, Robert M. Mentzer, Aleksandr Stotland, Roberta A. Gottlieb, Jennifer E. Van Eyk
    Journal Name: European Heart Journal
    Publisher: Oxford University Press (OUP)
    Vol: 46
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License:
    DOI - Digital Object Identifier: 10.1093/eurheartj/ehae782
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    Citation Count: 2
  • Incorporating label uncertainty during the training of convolutional neural networks improves performance for the discrimination between certain and inconclusive cases in dopamine transporter SPECT
    2024
    OPEN
    Title: Incorporating label uncertainty during the training of convolutional neural networks improves performance for the discrimination between certain and inconclusive cases in dopamine transporter SPECT
    Author(s): Aleksej Kucerenko, Thomas Buddenkotte, Ivayla Apostolova, Susanne Klutmann, Christian Ledig, Ralph Buchert
    Journal Name: European Journal of Nuclear Medicine and Molecular Imaging
    Publisher: Springer Science and Business Media LLC
    Vol: 52
    Issue #: 4
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s00259-024-06988-0
    Best OA location URL:
    Citation Count: 0
  • Associations of motor and neuropsychiatric symptoms with comorbidities in prodromal Parkinson’s disease
    2024
    OPEN
    Title: Associations of motor and neuropsychiatric symptoms with comorbidities in prodromal Parkinson’s disease
    Author(s): Jia-Ru Chen, Yan Sun, Ya‐Hui Ma, Lan Tan
    Journal Name: Frontiers in Aging Neuroscience
    Publisher: Frontiers Media SA
    Vol: 16
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.3389/fnagi.2024.1452766
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    Citation Count: 0
  • Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
    2024
    OPEN
    Title: Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles
    Author(s): Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen
    Journal Name: eLife
    Publisher: eLife Sciences Publications, Ltd
    Vol: 13
    Issue #:
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.7554/elife.92775.3
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    Citation Count: 1
  • The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
    2024
    RESTRICTED
    Title: The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
    Author(s): Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid‐Pellitero, Carol X.‐Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon Hassin‐Baer, Roy N. Alcalay, Austen J. Milnerwood, Thomas M. Durcan, Ziv Gan‐Or, Edward A. Fon
    Journal Name: Molecular Neurodegeneration
    Publisher: Springer Science and Business Media LLC
    Vol: 19
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License: cc-by
    DOI - Digital Object Identifier: 10.1186/s13024-024-00779-9
    Best OA location URL:
    Citation Count: 3
  • A multi-region single nucleus transcriptomic atlas of Parkinson’s disease
    2024
    OPEN
    Title: A multi-region single nucleus transcriptomic atlas of Parkinson’s disease
    Author(s): N. M. Prashant, John F. Fullard, Tereza Clarence, Deepika Mathur, Clara Casey, Evelyn Hennigan, Marcela Alvia, Joana Krause-Massaguer, Ayled Barreda, David A. Davis, Regina Vontell, Susanna P. Garamszegi, Jeffery M. Vance, Lorelle A. Sang, Michael Chatigny, David Vismer, Barry Landin, David E. Burstein, Donghoon Lee, Georgios Voloudakis, Sabina Berretta, Vahram Haroutunian, William K. Scott, Jaroslav Bendl, Panos Roussos
    Journal Name: Scientific Data
    Publisher: Springer Science and Business Media LLC
    Vol: 11
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1038/s41597-024-04117-y
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    Citation Count: 0
  • Benchmarking of a multi‐biomarker low‐volume panel for Alzheimer's disease and related dementia research
    2024
    OPEN
    Title: Benchmarking of a multi‐biomarker low‐volume panel for Alzheimer's disease and related dementia research
    Author(s): Laura Ibáñez, Menghan Liu, Aleksandra Beric, Jigyasha Timsina, Pat Kohlfeld, Kristy Bergmann, Joey Lowery, Nick Sykora, Brenda Sanchez‐Montejo, Will Brock, John Budde, Randall J. Bateman, Nicolas R. Barthélemy, Suzanne E. Schindler, David M. Holtzman, Tammie L.S. Benzinger, Chengjie Xiong, Rawan Tarawneh, Krista L. Moulder, John C. Morris, Yun Ju Sung, Carlos Cruchaga
    Journal Name: Alzheimer's & Dementia
    Publisher: Wiley
    Vol: 21
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1002/alz.14413
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    Citation Count: 3
  • A Highly-Efficient, Scalable Pipeline for Fixed Feature Extraction from Large-Scale High-Content Imaging Screens
    2024
    OPEN
    Title: A Highly-Efficient, Scalable Pipeline for Fixed Feature Extraction from Large-Scale High-Content Imaging Screens
    Author(s): Gabriel Comolet, N.K. Bose, Jeff Winchell, Alyssa Duren-Lubanski, Tom Rusielewicz, Jordan Goldberg, Grayson Horn, Daniel Paull, Bianca Migliori
    Journal Name: iScience
    Publisher: Elsevier BV
    Vol: 27
    Issue #: 12
    Start Page: 111434
    End Page: 111434
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc
    DOI - Digital Object Identifier: 10.1016/j.isci.2024.111434
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    Citation Count: 0
  • Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk
    2024
    OPEN
    Title: Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk
    Author(s): Elaine Guo Yan Chew, Zhehao Liu, Zheng Li, Sun Ju Chung, Michelle Mulan Lian, Moses Tandiono, Yue Jing Heng, Ebonne Ng, Louis C.S. Tan, Wee Ling Chng, Tiak Ju Tan, Esther KL Peh, Ying Swan Ho, Xiao Yin Chen, Erin YT Lim, Chu Hua Chang, Jonavan J. Leong, Ting Xuan Peh, Ling Ling Chan, Yinxia Chao, Wing‐Lok Au, Kumar M. Prakash, Jia Lun Lim, Yi Wen Tay, Vincent Mok, Anne Chan, Juei‐Jueng Lin, Beom S. Jeon, Kyuyoung Song, Clement C. Tham, Chi Pui Pang, Jeeyun Ahn, Kyu Hyung Park, Janey L. Wiggs, Tin Aung, Ai Huey Tan, Azlina Ahmad Annuar, Mary B. Makarious, Cornelis Blauwendraat, M. A. Nalls, Laurie Robak, Roy N. Alcalay, Ziv Gan-Or, Richard Reynolds, Shen‐Yang Lim, Yun Xia, Chiea Chuen Khor, Eng‐King Tan, Zhenxun Wang, Jia Nee Foo
    Journal Name: Nature Aging
    Publisher: Springer Science and Business Media LLC
    Vol: 5
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1038/s43587-024-00760-7
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    Citation Count: 3
  • Genome Aggregation Database Version 4—Allele Frequency Changes and Impact on Variant Interpretation in Dystonia
    2024
    OPEN
    Title: Genome Aggregation Database Version 4—Allele Frequency Changes and Impact on Variant Interpretation in Dystonia
    Author(s): Elisabetta Indelicato, Anja Eberl, Sylvia Boesch, Lara M. Lange, Christine Klein, Katja Lohmann, Michael Zech
    Journal Name: Movement Disorders
    Publisher: Wiley
    Vol: 40
    Issue #: 2
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1002/mds.30066
    Best OA location URL:
    Citation Count: 0
  • Longitudinal decline in DAT binding in Parkinson’s disease: connections with sleep disturbances
    2024
    OPEN
    Title: Longitudinal decline in DAT binding in Parkinson’s disease: connections with sleep disturbances
    Author(s): Junli Ren, Haobo Xie, Yiyun Weng, Yaoying Ge, Ruotong Yao, Zihan Jiang, Jinxiu Zhang, Yusheng Zhu, Xiaotong Fu, Junchao Wang, Zijia Liu, Shishu Zhang, Tingxuan Zhang, Guangyong Chen, Dehao Yang
    Journal Name: BMC Medicine
    Publisher: Springer Science and Business Media LLC
    Vol: 22
    Issue #: 1
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by-nc-nd
    DOI - Digital Object Identifier: 10.1186/s12916-024-03766-5
    Best OA location URL:
    Citation Count: 0
  • High‐molecular‐weight oligomer tau (HMWoTau) species are dramatically increased in Braak‐stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)
    2024
    OPEN
    Title: High‐molecular‐weight oligomer tau (HMWoTau) species are dramatically increased in Braak‐stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)
    Author(s): Hiroaki Fukumoto, Tzu‐Huei Kao, Chin‐Yin Tai, Ming‐Kuei Jang, Masaomi Miyamoto
    Journal Name: The FASEB Journal
    Publisher: Wiley
    Vol: 38
    Issue #: 22
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1096/fj.202401704r
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    Citation Count: 0
  • Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l -DOPA–induced dyskinetic behaviors
    2024
    RESTRICTED
    Title: Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l -DOPA–induced dyskinetic behaviors
    Author(s): Beatriz E Nielsen, Christopher Ford
    Journal Name: Science Advances
    Publisher: American Association for the Advancement of Science (AAAS)
    Vol: 10
    Issue #: 47
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: RESTRICTED
    License:
    DOI - Digital Object Identifier: 10.1126/sciadv.adp6301
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    Citation Count: 1
  • Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach
    2024
    OPEN
    Title: Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach
    Author(s): Leonor Lopes, Fangyang Jiao, Song Xue, Thomas Pyka, Korbinian Krieger, Jingjie Ge, Qian Xu, Rachid Fahmi, Bruce Spottiswoode, Ahmed A. Soliman, Ralph Buchert, Matthias Brendel, Jimin Hong, Yihui Guan, Claudio L. Bassetti, Axel Rominger, Chuantao Zuo, Kuangyu Shi, Ping Wu
    Journal Name: European Journal of Nuclear Medicine and Molecular Imaging
    Publisher: Springer Science and Business Media LLC
    Vol: 52
    Issue #: 3
    Start Page:
    End Page:
    Publication Date:
    Open Access(OA) Status: OPEN
    License: cc-by
    DOI - Digital Object Identifier: 10.1007/s00259-024-06961-x
    Best OA location URL:
    Citation Count: 2
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