The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Examining GCase Activity in People with REM Sleep Behavior Disorder
Study Rationale:
Approximately 80 percent of people with REM sleep behavior disorder (RBD) will develop a neurological disorder such as Parkinson's disease (PD). GBA mutations are the most frequent... -
Research Grant, 2018Tracing Hallmarks of Parkinson's Disease in the Brain with a New Compound
Study Rationale:
Parkinson's disease (PD) is characterized by the presence of protein alpha-synuclein clumps in the brain. PD shares common features with other neurodegenerative diseases and because an... -
LRRK2 Biology Consortium, 2018Developing Cell-Based Tools for the Evaluation of LRRK2 Inhibitors
Promising Outcomes of Original Grant:
Mutations in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD) and cause dysfunction in the LRRK2 protein. We have previously demonstrated... -
Research Grant, 2018Developing a Reliable Clinical Test for pS129 Alpha-synuclein
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). An abnormal form of the protein, called pS129 alpha-synuclein, can serve as an... -
Mitochondrial Biomarkers, 2018Studying Changes in Phosphatidylethanolamine as a New Marker of Parkinson's Disease
Study Rationale:
While most cases of Parkinson's disease (PD) have no known cause, some are caused by changes (mutations) in genes such as SNCA, which regulates the production of a protein called alpha... -
Research Grant, 2018Development of Experimental Setups Using New Antibodies to Detect Alpha-synuclein in Cerebrospinal Fluid
Study Rationale:
Research studies have yet to clearly explain whether alpha-synuclein oligomers -- clumps of protein alpha-synuclein -- in biologicals fluids can be used in clinics as measures of...
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Our funding programs support basic, translational and clinical research from academia and industry.