The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Target Advancement Program, 2017Activation of PINK1/Parkin-mediated Mitochondrial Quality Control
Study Rationale:
Homeostasis (balance) of mitochondria, the powerhouses of cells, is crucial for longevity. Accumulation of damaged mitochondria is toxic for cells, which is believed to be one of the... -
LRRK2 Biology Consortium, 2017How Does LRRK2 Activity Affect Inflammatory Signaling in Parkinson's Disease?
Study Rationale:
Differences in the leucine-rich repeat kinase 2 (LRRK2) gene can increase the risk of developing Parkinson's disease (PD), and there is an abundance of the LRRK2 protein in blood... -
Research Grant, 2017Developing Disease-modifying Chemical Probes to Inhibit Alpha-synuclein Accumulation
Promising Outcomes of Original Grant:
Funding from The Michael J. Fox Foundation (MJFF) has facilitated the rapid screening of over 370,000 compounds of chemicals that prevent alpha-synuclein (protein... -
Research Grant, 2017Identification and Optimization of beta-Glucocerebrosidase Modulators for Parkinson's Disease
Study Rationale:
Genetic studies have demonstrated that the GBA1 gene encoding beta-glucocerebrosidase (GCase) (an enzyme that breaks down fats) is a major risk factor for Parkinson's disease (PD)... -
Improved Biomarkers and Clinical Outcome Measures, 2017Neuron-restricted RNA Profiles in the Plasma of Those with Genetic and Sporadic Parkinson's Disease
Study Rationale:
MicroRNAs (miRs) are short RNA molecules (messengers that carry genetic information to DNA) that block protein expression by crossing with hundreds of mRNA targets. Neuron-restricted... -
Research Grant, 2017Phase IIa Safety and Tolerability Trial of Nilotinib in People with Parkinson's Disease
Study Rationale:
Previous research has shown higher levels of the c-Abl protein are activated in the brains of people with Parkinson's disease (PD), and studies have linked c-Abl to pathways associated...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.