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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Community Fast Track, 2005
    The role of serotonin neurons in the induction and maintenance of dyskinesias in grafted and L-DOPA-primed animals

    Background: Levodopa, the most commonly used medication for patients with Parkinson's disease, is a beneficial therapy, but as the disease progresses it can be the cause of debilitating involuntary...

  • LEAPS, 2005
    New Small Molecule Inhibiting Agents of Alpha-Synuclein & Lewy Body Formation as Disease-Modifying Treatments for Parkinson's Disease

    Parkinson's Disease is pathologically characterized by the presence and accumulation of a protein known as alpha-synuclein. Mutations in alpha-synuclein have been directly linked to PD, and alpha...

  • LEAPS, 2005
    Development and Optimization of a Regulatable Gene Switch for Gene Therapies of Parkinson’s Disease

    Gene therapy holds tremendous potential for the treatment of Parkinson's disease. By using a virus or other DNA delivery system to permanently insert a new gene into critical regions of a Parkinson...

  • Clinical Discovery Awards, 2005
    Executive, ADL, and Cholinergic Functions in PD

    Parkinson's disease is a disorder that is most known for motor impairments of tremor, slowness in moving, and loss of balance. Patients with Parkinson's disease also suffer from non-motor symptoms...

  • Clinical Discovery Awards, 2005
    Ability to Slow Disease Progression and Safety and Tolerability of Green Tea Polyphenols in Early Parkinson’s Disease

    Objective/Rationale:
    Previous studies have shown that tea drinking is associated with a reduced of risk for Parkinson's disease (PD). Green tea polyphenols (GTPs), the major components of green tea...

  • Clinical Discovery Awards, 2005
    Dysfunction of the Blood-Brain Barrier: The Cause of Parkinson's Disease

    The causes of Parkinson's disease are still unclear. Genetic vulnerability and exposure to environmental neurotoxins are assumed to be contributors to nerve cell loss (neurodegeneration) in certain...

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