Mrs. Speyer is the co-founder of Never Stop Learning (NSL), which curates talks on themes as diverse as foreign policy to food in private and corporate settings. Prior to her involvement with NSL, Mrs. Speyer lent her expertise as a marketing consultant, having worked in fashion marketing for 15 years at such companies as Calvin Klein, Donna Karan and Iconix Brand Group. She also serves on the boards of the Whitney Museum of American Art and Ballroom Marfa.

Mrs. Speyer earned a BA from Cornell University and an MBA from New York University. She and her husband reside in New York.