The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2011Caspase- 1 Inhibition to Reduce Cleaved Alpha-synuclein in Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
We will test the hypothesis that caspase-1 inhibition will down- regulate α-synuclein (α-SYN) at mRNA and/or protein levels within the SN and restore impaired function of the... -
Defining Cognitive Phenotypes of Parkinson’s Disease, 2011Development of Multimodal Imaging Biomarkers for Cognitive Dysfunction in Parkinson's Disease
Objective/Rationale:
By the time a person with Parkinson’s disease (PD) meets diagnostic criteria for dementia, the brain has already been ravaged. Unfortunately, current clinical, neuropsychological... -
Therapeutics Development Initiative, 2011Lead Optimization and Pharmacological Characterization of Selective mGluR3 PAMs as Novel Neuroprotective Agents for Parkinson's Disease
Objective/Rationale:
mGluR3 is a novel target that could lead to neuroprotection through production of GDNF and TGF-beta in striatal neurons. The goals of the current project are first to optimize... -
MJFF Research Grant, 2011Alpha-synuclein Expression Lowering therapeutics: Hit Confirmation
Objective/Rationale:
Simply increasing dosage of the wild-type alpha-synuclein gene (SNCA) is sufficient to cause dopaminergic neurodegeneration and Parkinson’s disease in rare families carrying an... -
LRRK2, 2011Identification of the LRRK2 Phosphatase
Objective/Rationale:
Exactly how Parkinson’s disease (PD) develops is not known, however current research indicates that the leucine rich repeat kinase 2 (LRRK2) protein plays a central role in the... -
Rapid Response Innovation Awards, 2011Use of HspB1 Chaperone to Inhibit Pathological Alpha-synuclein Aggregation
Objective/Rationale:
The misfolding and aggregation of the protein alpha-synuclein has been identified as pivotal event causing Parkinson's disease. All cells in our body possess so-called chaperones...
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Our funding programs support basic, translational and clinical research from academia and industry.