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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    Probing the Function of SGK1 and its Relationship to LRRK2 and Parkinson’s Disease

    Objective/Rationale:
    Genetic testing of 3,500 Parkinson’s disease (PD) patients revealed that mutations in serum glucocorticoid-regulated kinase 1 (SGK1) gene reverts the risk of getting Parkinson’s...

  • MJFF Research Grant, 2010
    Male transgenic rat Parkinson's disease model characterization

    Promising Outcomes of Original Grant:
    The original project focused on the creation and characterization of pre-clinical models that express mutations in the protein alpha-synuclein that are known to...

  • Biomarkers, 2010
    Oxidized DJ-1 as a Biomarker for Parkinson's Disease

    Objective/Rationale
    Mutations in the DJ-1 gene are associated with an early-onset familial form of PD and DJ-1 protein has been shown to be decreased in the CSF of sporadic PD compared to controls. ...

  • Target Validation, 2010
    Pharmacological PHD Inhibition as a Potential PD Neuroprotectant Therapy

    Objective/Rationale
    A growing body of evidence suggests that iron dysregulation may contribute to neurodegeneration associated with Parkinson’s disease (PD). Recent work from our laboratory suggests...

  • Rapid Response Innovation Awards, 2010
    Protecting Innervation: Nmnat1 Gene Therapy for Parkinson's Disease

    Objective/Rationale
    Axonal degeneration is a major pathological hallmark of Parkinson’s disease (PD). Evidence gathered in PD patients indicates that pathology in axons occurs prior to and...

  • Rapid Response Innovation Awards, 2010
    Genetic-epidemiological Confirmation of Top Hits of GWAS of Parkinson Disease: A Large Multi-center Collaborative Study

    Objective/Rationale
    A critical question which is still unresolved in the post GWAS (genome-wide association study) era focuses on the role of non genetic factors conferring either a risk or...

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Our funding programs support basic, translational and clinical research from academia and industry.

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