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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2010
    Development of a Progressive Familial Pre-clinical Model of Parkinson's Disease

    Objective/Rationale
    Although a number of genes have been identified that lead to Parkinson’s disease in humans, the scientific community has yet to be able to recapitulate this in pre-clinical...

  • Critical Challenges in PD: Alpha-synuclein Neuroimaging, 2010
    Development and Screening of Contrast Agents for In-vivo Imaging of Parkinson's Disease

    Promising Outcomes of Original Grant:
    The goals of the original grant were to screen a library of compounds to identify leads for non-invasive imaging of PD pathology. We used cell culture models of...

  • Rapid Response Innovation Awards, 2010
    Development of In-vivo Models of Prion-like Transfer of Alpha-synuclein

    Promising Outcomes of Original Grant:
    We aimed at assessing the prion-like hypothesis of alpha-synuclein spread. Prions are small proteins that can move between cells, acting as infectious agents...

  • MJFF Research Grant, 2010
    In-vivo SPECT Imaging of Synuclein Aggregation with Morphology Specific Antibody Based Ligands

    Promising Outcomes of Original Grant:
    The protein alpha-synuclein (a-syn) has been strongly correlated with PD, and small a-syn aggregates are very toxic and may be an early indicator of the disease...

  • Therapeutics Development Initiative, 2010
    Selective Inhibition of Cyclic Nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease

    Promising Outcomes of Original Grant:
    We are investigating a regulatory enzyme (type-7 cyclic nucleotide phosphodiesterase, PDE7) as a novel therapeutic target for the treatment of Parkinson’s disease...

  • Rapid Response Innovation Awards, 2010
    Biofeedback-based Motor Learning to Ameliorate Freezing of Gait

    Objective/Rationale:  
    Our objective is to demonstrate that an intervention program based on motor learning principles can be applied to train subjects with Parkinson's disease (PD) who suffer from...

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