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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2009
    Validation of Dyskinesia Rating Scales

    Objective/Rationale:
    Dyskinesias, or involuntary jerking movements, are troublesome problems for many Parkinson’s disease patients. Chemical studies have led to the development of several new...

  • Rapid Response Innovation Awards, 2009
    Plasma Biomarker Screen for Neurodegeneration and Signaling Proteins

    Objective/Rationale:
    The cells and tissues of the body can “communicate” with one another using small secreted proteins that can be found in the blood. There are several hundred of these cellular...

  • Rapid Response Innovation Awards, 2009
    Oligomeric Equilibrium in Male and Female Brains with Alpha-synuclein Pathology

    Objective/Rationale:
    Men are more susceptible to Parkinson's disease than women. Alpha-synuclein aggregates are a hallmark of the disease and it is increasingly believed that alpha-synuclein...

  • Rapid Response Innovation Awards, 2009
    Characterizing Transgenic Pre-Clinical Models that Express a Mutant LRRK2 Gene Selectively in Adulthood

    Objective/Rationale:
    Mutations of the gene LRRK2 are identified in both familial and sporadic Parkinson’s disease (PD). How mutation of the LRRK2 gene causes neuronal dysfunction in PD remains to be...

  • Postural Instability and Gait Disturbances, 2009
    Role of the Posterior Parietal Cortex and Pedunculopontine Nucleus in the Pathophysiology of Freezing of Gait: An MRI and TMS Study

    Objective/Rationale:
    Although disturbances in the posterior parietal cortex (PPC) and pedunculopontine nucleus (PPN) are thought to be involved in the development of freezing of gait (FOG) in PD...

  • Postural Instability and Gait Disturbances, 2009
    Neuroanatomical Correlates of Dopamine Responsive and Non-responsive Gait and Balance Impairment in Parkinson's Disease

    Objective/Rationale:
    Parkinson’s is more than a motor disorder that responds to dopamine replacement. Dopamine non-responsive features account for much of the disability that develops with disease...

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