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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2008
    Generation of a dorsal motor nucleus X (DMX) specific pre-clinical model of alpha synuclein overexpression to study the etiology of autonomic dysfunction in PD

    Objective/Rationale:
    The etiology for the non-motor symptoms in PD, such as autonomic instability, sleep disturbance, and constipation, remain poorly understood. In their recent studies of PD...

  • MJFF Research Grant, 2008
    GDNF Fusion Protein for Blood-Brain Barrier Delivery and Treatment in Parkinson's Disease

    Objective/Rationale:

    GDNF is a naturally occurring protein in the brain that protects and rescues the part of the brain that degenerates in Parkinson’s disease (PD). However, GDNF does not cross the...

  • MJFF Research Grant, 2008
    The anatomic basis of cardiac and cognitive changes in Parkinson's disease: A collaborative study with the Parkinson's Institute, Sunnyvale, CA (USA)

    Objective/Rationale:
    The heart, particularly the conduction system, is influenced by the parasympathetic and sympathetic nervous systems. Recently, early-occurring Parkinson’s disease-related Lewy...

  • Program-non-specific Funding, 2008
    Evaluation of Pioglitazone CSF Penetration

    Promising Outcomes of Original Grant:
    In our original grant we assessed whether the antidiabetic compound pioglitazone can be neuroprotective in a non-human primate model of Parkinson’s disease. We...

  • Program-non-specific Funding, 2008
    Evaluation of Neuroprotective Properties of Selective PPAR Gamma Agonist LY554862

    Objective/Rationale:
    Low-risk, easily administered therapies aiming to slow down or stop neurodegeneration in PD are urgently needed. Compounds that activate PPAR gamma receptors have the potential to...

  • MJFF Research Grant, 2008
    Evaluation of Gastrointestinal Motility in Parkinsonian Rodents

    Objective/Rationale:
    Gastrointestinal (GI) symptoms, such as nausea, bloating, and constipation occur in nearly every patient afflicted with Parkinson’s Disease (PD) at some point in their illness...

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Our funding programs support basic, translational and clinical research from academia and industry.

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