The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers, 2005Reduction of NURR1 mRNA in Human Peripheral Blood Lymphocytes as a Biomarker of PD
Parkinson's disease is a common neurodegenerative disease in adults, affecting over 1 million people in the United States. The neuropathology in the brain has been progressing long before the clinical...
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Biomarkers, 2005Epigenetic Regulation of the alpha-synuclein Gene as a Biomarker of Susceptibility to PD
Available genetic information in Parkinson's disease does not account for all phenomena in the clinical expressivity of the disease. For example, in the Contursi kindred with the A53T substitution in...
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Biomarkers, 2005Biomarkers in Human Cerebrospinal Fluid
This proposal involves confirmatory as well as discovery-type proteomic analyses of protein profiles in the human cerebral spinal fluid (CSF) obtained from patients with Parkinson's disease (PD) at...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2005Engineering Midbrain Dopamine Neurons by Forced Expression of a Novel Dopamine Cell Determinant in Pre-Clinical Model Embryonic Stem Cells
Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...
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Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2004In Vitro Electrophysiological Studies in Experimental Models of Dyskinesias
Although levodopa is one of the most effective therapies for Parkinson’s disease, particularly in the early stages, chronic treatment leads to the development of dyskinesias or movement abnormalities...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Identification of Novel Determinants for Dopamine Neuron Generation in Vivo and in Embryonic Stem Cells
Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...
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Our funding programs support basic, translational and clinical research from academia and industry.