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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2015
    Amelioration of Mitochondrial Oxidant Stress by Isradipine and Rasagiline

    Study Rationale:                   
    The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons. One potential cause of this degeneration is calcium...

  • Biomarker Development, 2015
    Biomarker and DNA Samples Collection Add-on Study to the Phase III Trial of Isradipine

    Study Rationale:
    Isradipine, an FDA-approved agent for treatment of high blood pressure, was shown to be have neuroprotective benefit in models of Parkinson’s disease (PD).  A recently completed Phase...

  • Access to Data and Biospecimens, 2015
    Validation of a Blood-based Gene Expression Assay for Early Diagnosis and Monitoring Disease

    Study Rationale:                   
    The need for biomarkers in Parkinson’s disease (PD) is crucial for the early diagnosis of PD; monitoring PD severity/progression; and developing treatments that can...

  • Research Grant, 2015
    Pre-clinical Development of the Oligomer Modulator anle138b and Establishment of a Novel Seeding-based Biomarker

    Promising Outcomes of Original Grant:
    In our previous work, we assessed the therapeutic potential of the oligomer modulator anle138b in pre-clinical models of Parkinson’s disease (PD). Anle138b...

  • Target Validation, 2015
    Enhancing Mitochondria Quality Control in Parkinson’s via Activation of the Caseinolytic Peptidase

    Study Rationale:                   
    Reinforcement of mechanisms that maintain the health of the cell’s energy generator, its mitochondria, may combat age-related diseases including Parkinson’s disease...

  • Target Validation, 2015
    Modulation of Microglia Cannabinoid Receptor 2 to Treat Neuroinflammation in Parkinson’s Disease

    Study Rationale:                   
    Numerous studies have highlighted a potential role of neuroinflammation in Parkinson’s disease whereby the immune cells of the brain called microglia may produce...

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