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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2015
    Comparison of Nedd4 and GBA for Improving Protein Handling and Reducing Alpha-synucleinopathy

    Study Rationale:                   
    Lysosomes are key intra-cellular organelles involved in the degradation of proteins including alpha-synuclein. Lysosomal protein degradation systems fail in...

  • Target Validation, 2015
    Pathogenetic Mechanisms in Early-onset Parkinsonism Resulting from a Mutation in the Synaptojanin 1 Protein

    Study Rationale:                   
    Several proteins encoded by Parkinson’s disease (PD) genes have been linked to vesicular traffic (movement of molecules) at synapses (junctions between neurons)...

  • Target Validation, 2015
    Validation of the Rip Kinase Pathway as a Therapeutic Target in Parkinson's Disease

    Study Rationale:
    A genetic connection has been shown over the past few years between Parkinson’s and Gaucher’s diseases, such that people with genetic mutations that cause Gaucher’s disease have a...

  • Improved Biomarkers and Clinical Outcome Measures, 2015
    Validation of a Performance-based Assessment of Functional Ability Related to Cognition in Parkinson’s Disease

    Study Rationale:                   
    There is a pressing need for new treatments to address cognitive impairment in Parkinson’s disease, yet there is no consensus on how to best evaluate their...

  • Target Advancement Program, 2015
    Study of the Molecular and Cellular Consequences of LRRK2 Kinase Inhibition in Neurons and Microglia

    Study Rationale:
    Mutations in leucine-rich repeat kinase-2 (LRRK2) are the greatest known genetic cause of Parkinson’s disease (PD). LRRK2 inhibitors may represent a new type of disease-modifying...

  • Target Advancement Program, 2015
    LRRK2 and Insulin Signaling

    Study Rationale:                   
    Mutations in the LRRK2 gene may contribute to the development of familial and sporadic Parkinson’s disease (PD). Examination of the physiological role of the LRRK2...

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