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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Postural Instability and Gait Disturbances, 2009
    Relationship between REM Behavior Disorder and Freezing of Gait in Parkinson's Disease

    Objective/Rationale:
    Many people with REM sleep behavior disorder (RBD), a disease associated with disturbance of sleep, eventually develop Parkinson’s disease. Dysfunction and degeneration of...

  • Postural Instability and Gait Disturbances, 2009
    Determining the Neural Correlates of Freezing of Gait in Parkinson's Disease Using Functional Magnetic Resonance Imaging

    Objective/Rationale:
    Freezing of Gait (FOG) in Parkinson’s disease occurs when a person’s feet become suddenly ‘frozen’ while walking or turning. FOG is a leading cause of falls, and responds poorly to...

  • MJFF Research Grant, 2009
    Pilot Assessment of the Effect of Optimism and Expectation on Dyskinesia Rating Scales in Parkinson's Disease Subjects Randomized to Placebo or Amantadine

    Objective/Rationale:
    The effects of placebo response in clinical and surgical interventions in PD have become increasingly recognized. Many factors have been associated with placebo response including...

  • Therapeutics Development Initiative, 2009
    IMD-026259 An Innovative Drug for Disease-Modifying Treatment of Parkinson´s Disease

    Objective/Rationale:
    Parkinson’s disease progresses through the death of brain cells caused by “oxidative stress.” This takes place in dysfunctional mitochondria - structures within each cell...

  • Therapeutics Development Initiative, 2009
    Potential Efficacy of a Novel HDAC Inhibitor in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale:
    Histone deacetylases (HDACs) are a family of enzymes that reduce gene expression and can regulate protein clearance. Inhibitors of HDACs have been reported to be efficacious in...

  • Therapeutics Development Initiative, 2009
    Development of Anti-toll-like Receptor (TLR)-2 Monoclonal Antibody as a Therapeutic Agent in Parkinson's Disease

    Objective/Rationale:
    Parkinson’s is associated with an inflammatory response, which in the brain is mainly mediated by cells called microglia. Inflammation is normally beneficial helping us fight...

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