The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013Longitudinal Characterization of G2019S Models: Physiological and Behavioral Analyses of Dopamine and Glutamate Systems
Objective/Rationale:
It is likely in disease states that brain cells suffer long periods of dysfunction before they die. By studying the early effects of Parkinson’s disease (PD) gene mutations upon... -
LRRK2 Pharmacodynamic Assays, 2013Monocyte Monitoring in LRRK2-associated Parkinson’s Disease
Objective/Rationale:
LRRK2 variants significantly contribute to the development of familial and sporadic Parkinson’s disease (PD). However, it is not yet understood how LRRK2 mutations cause cellular... -
Research Grant, 2013Evaluation of a LRRK2 Inhibitor in the Partial 6-OHDA-lesioned Model of Parkinson’s Disease
Objective/Rationale:
Mutations in the LRRK2 gene are the most common cause of familial Parkinson’s disease (PD). The existing human genetic, cell-based and model data suggest that LRRK2 kinase... -
Research Grant, 2013Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease
Objective/Rationale:
The age of onset and penetrance (likelihood of disease) of individuals with the LRRK2 G2019S mutation varies considerably, the latter ranging in some families from as high as 100... -
Cognition Biomarkers, 2013Validation of Novel and Traditional Quantitative EEG Biomarkers
Objective/Rationale:
Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD... -
LRRK2 Challenge, 2013Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
Objective/Rationale:
Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the...
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Our funding programs support basic, translational and clinical research from academia and industry.