The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
- Inflammation
- 4
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Research Grant, 2020Targeting TNFR2 in a Model of Parkinson’s Disease
Study Rationale:
In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous... -
Target Advancement Program, 2020Evaluating the Role of Natural Killer Cells in Parkinson's Pathology
Promising Outcomes of Original Grant:
Our original study investigated whether immune cells called human natural killer (NK) cells play a protective role on the nervous system in Parkinson’s disease... -
Research Grant, 2019Long-acting GM-CSF Fusion Protein (PDM608) for the Treatment of Parkinson’s Disease
Study Rationale:
Emerging evidence suggests that the modulating the peripheral immune system can be a powerful disease-modifying approach for the treatment of Parkinson's disease (PD). We have... -
Astrocyte Biology in Parkinson's Disease, 2019Exploring Proteins associated with Alpha-synuclein in Astrocytes at Different Stages of Parkinson’s Disease
Study Rationale:
In addition to neurons, astrocytes are the other major cell type that have increased alpha-synuclein in Parkinson’s disease (PD). In fact, more astrocytes have increased alpha... -
Improved Biomarkers and Clinical Outcome Measures, 2019Development of a Colony Stimulating Factor 1 Receptor (CSF1R) Radioligand for Imaging Microglia-selective Inflammation
Study Rationale:
We have shown that Parkinson’s disease has an underlying neuroinflammatory component that involves microglia, which are inflammatory and immune cells in the brain. We have developed... -
Research Grant, 2019Pathogenesis of the Virome in Parkinson’s Disease
Study Rationale:
Numerous studies have implicated viruses as causal factors or potential triggers for Parkinson’s disease (PD). Our study will provide a comprehensive understanding of all the viral...
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