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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2018
    Purine Biomarkers of LRRK2-Associated Parkinson's Disease

    Objective/Rationale:
    Oxidative damage to brain cells - akin to rust on car parts - builds up in Parkinson's disease (PD) and leads to breakdown of brain functions. Urate is a natural antioxidant that...

  • Research Grant, 2018
    Developing New Tracers for Imaging Synapses in the Brain

    Study Rationale:
    A synapse is a point of contact between a nerve cell and another cell that allows them to communicate. In the brain, changes in the number of synapses (synaptic density) are associated...

  • Research Grant, 2018
    Searching for New Causes of LRRK2-associated Parkinson's Disease

    Study Rationale:
    Mutations (changes) in the LRRK2 gene are a leading genetic cause of Parkinson's disease (PD) and cause dysfunction in the LRRK2 protein. However, not all LRRK2 mutations cause the...

  • Alpha-synculein Biology and Therapies, 2018
    Supporting Alpha-synuclein Attachment to Synaptic Vesicles for the Treatment of Parkinson's Disease

    Study Rationale:
    Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). Researchers believe that alpha-synuclein clumps can damage nerve cells in the...

  • Research Grant, 2018
    Autophagy and Mitochondrial Dysfunction as Potential Therapeutic Targets in Inherited Parkinson's Disease

    Study Rationale:
    Mutations (changes) in the gene that controls the production of enzyme glucocerebrosidase (GCase) are the most common risk factor for inherited Parkinson's disease (PD). We have...

  • Research Grant, 2018
    Assessing Proteins LRRK2, GCase and Cytokines in Immune Cells

    Study Rationale: 
    Leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are two proteins linked to an increased risk of developing Parkinson’s disease (PD). Both proteins are produced by...

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