The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2017Improving Participation in Clinical Trials in Individuals with Atypical Parkinsonian Syndromes through Virtual Research Visits (ImPaCT-Atypical)
Objective/Rationale:
The Michael J. Fox Foundation's Fox Trial Finder is designed to facilitate and increase the participation of individuals with Parkinson's disease (PD) and degenerative... -
Therapeutic Pipeline Program, 2017Advancing Neuroprotective Protein Regulators Toward the Clinical Candidate Phase
Study Rationale:
Addex Pharmaceuticals has developed drug discovery tools that can be used to screen its small molecule compound library for positive allosteric modulators (protein regulators) of TrkB... -
Therapeutic Pipeline Program, 2017Protein Homeostasis and the Ubiquitination Pathway in Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) involves accumulation of toxic proteins in cells in specific areas of the brain. These cells normally have protective mechanisms to remove these toxic... -
Research Grant, 2017Development of Analytic Tests to Use as Nilotinib Companion Diagnostics in Parkinson's Disease
Study Rationale:
Evidence suggests that increased activity of the c-abl protein in the brain may contribute to the development and progression of Parkinson's disease (PD). Nilotinib, a drug that... -
Research Grant, 2017White Blood Cell and Urine Collection in LRRK2 and GBA Mutation Carriers
Study Rationale:
Mutations in the LRRK2 and GBA genes increase the risk for Parkinson's disease (PD). The mechanism by which these mutations increase PD risk is unknown. One potential explanation may...
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Therapeutic Pipeline Program, 2017Small-Molecule Pharmacological Chaperones Reverse Alpha-synuclein-impaired Debris Removal
Study Rationale:
The goal of this project is to find therapeutic drugs for Parkinson's disease (PD) that target alpha-synuclein, a key player in PD. We propose that the negative impact of alpha...
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Our funding programs support basic, translational and clinical research from academia and industry.