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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2020
    Quantification of S129 Phosphorylated Alpha-Synuclein Using the AlphaLISA Immunoassay Platform

    Study Rationale:
    In Parkinson's, there remains an unmet need for biomarkers to track disease progression and efficacy of potential therapies. This team of investigators is focused on fluid-based...

  • Improved Biomarkers and Clinical Outcome Measures, 2020
    PPMI DATIQ and SR T1w MRI Analysis

    Study Rationale:
    Parkinson’s disease results in functional and structural changes in the brain. Non-invasive imaging methods such as SPECT and MRI can measure these changes. The dopamine transporter...

  • Target Advancement Program, 2020
    Gene Therapy Approach to Reduce Alpha‐synuclein Aggregation in a Model of Parkinson's

    Study Rationale:
    A hallmark of Parkinson’s disease is the accumulation of an abnormal form of the protein alpha-synuclein inside brain cells. The team plans to use a gene therapy approach to insert a...

  • Improved Biomarkers and Clinical Outcome Measures, 2020
    Development of a Non-Invasive Ophthalmic Diagnostic for Parkinson’s Disease

    Study Rationale:
    Currently, diagnosis of Parkinson’s disease relies on extensive neurological and physical examinations. A hallmark of Parkinson's is misfolded alpha-synuclein that forms aggregates...

  • Therapeutic Pipeline Program, 2020
    Adaptive Deep Brain Stimulation for Gait Retraining in Parkinson's Disease

    Study Rationale:
    Walking impairment in people with Parkinson’s disease (PD) often arises from difficulties in coordinating leg movements in response to environment changes. Continuous stimulation of...

  • Alpha-Synuclein Imaging, 2020
    PET Imaging Probe Development for Alpha-synuclein
    Ken Griffin Alpha-synuclein Imaging Competition Logo

    Study Rationale:
    Alpha-synuclein is a protein that can clump to form Lewy bodies and lewy neurites, which are a hallmark of Parkinson's disease. Being able to identify these clumps in living patients...

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