The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019Functional Evaluation of Alpha-synuclein Dosage Effects in CRISPR‐edited SNCA Model
Promising Outcomes of Original Grant:
The goal of our original grant was to develop a patient-derived stem cell model from skin cells with different expression levels of protein alpha-synuclein, which... -
Target Advancement Program, 2019Targeting Necroptosis to Stop Axonal Degeneration in Parkinson's Disease
Study Rationale:
Parkinson’s disease (PD) is caused by degeneration of dopamine neurons. Neurons are constituted by a cell body and projections called axons by which neurons communicate... -
Therapeutic Pipeline Program, 2019CRISPRi/dCas9 Downregulation of Alpha-synuclein as a Novel Gene Therapy
Study Rationale:
Neurodegeneration in the brains of people with Parkinson’s may be caused by protein clumps called Lewy bodies, the pathological hallmark of the disease. Lewy bodies consist of a... -
Improved Biomarkers and Clinical Outcome Measures, 2019Correlating MRI, Pathology and Cognitive Assessments toward Biomarkers of Cognitive Decline
Study Rationale:
Parkinson’s studies are working to identify magnetic resonance imaging (MRI) biomarkers for early diagnosis, disease severity and progression. However, attempts to explore how brain... -
Research Grant, 2019Longitudinal Examination of Problems that Bother People with Parkinson’s
Study Rationale:
Using the Fox Insight research platform, we extracted and analyzed reports in patients’ own words about what problems bother them and how these problems affect their daily functioning... -
Therapeutic Pipeline Program, 2019Clinical Development of AKST4290 as a Novel Parkinson’s Therapeutic
Study Rationale:
There is clear evidence that the immune system plays an important role in the development and progression of Parkinson's disease. Novel therapies targeting the recruitment of immune...
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Our funding programs support basic, translational and clinical research from academia and industry.