The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019PET Tracer to Support Trials of Drugs Inhibiting Neuroinflammation via the NLRP3 Inflammasome
Study Rationale:
Chronic inflammation of immune cells our brains is now believed to be associated with the onset and progression of Parkinson’s disease. These cells produce a target in Parkinson’s... -
Alpha-Synuclein Biology and Therapies, 2019Studying the Impact of Alpha-synuclein on Fatty Substances to Identify New Parkinson's Disease Drug Targets
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). It can attach itself and interact with fatty substances called lipids and fatty... -
Research Grant, 2019Diagnosing Early-Stage Parkinson’s Disease via a Urine Test for Extracellular Vesicles
Objective/Rationale:
There is a great need to develop new, readily accessible biomarkers — objective measures of disease — from biofluids (blood, urine, saliva or cerebrospinal fluid) for early... -
Research Grant, 2019Pharmacological Targeting of Inflammasome Activation Mechanisms in Synuclein Models of Parkinson's Disease
Promising Outcomes of Original Grant:
Our previous studies confirmed the activation of an immune system complex called the inflammasome is involved in chronic inflammation and the death of brain cells... -
Research Grant, 2019Antibodies Blocking Alpha-synuclein Toxicity and Spread for the Treatment of Parkinson’s Disease
Study Rationale:
Two main hallmarks of Parkinson’s disease (PD) are neurodegeneration and Lewy bodies, protein clumps comprising mainly of the protein alpha-synuclein. In diseases such as Parkinson’s... -
Research Grant, 2019Small Molecules That Promote Mitochondrial Movement as a Parkinson's Disease Therapy
Promising Outcomes of Original Grant:
Deficit in the movement of mitochondria -- powerhouses of the cell -- have been implicated in Parkinson's disease (PD) and other neurodegenerative diseases. We...
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Our funding programs support basic, translational and clinical research from academia and industry.