The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2022Assessing the Neuroprotective Factor REST/NRSF as a Therapeutic Target for Parkinson’s Disease
Study Rationale: Evidence suggests that a regulatory factor called REST (also known as NRSF) could promote the survival of neurons in neurodegenerative conditions. Studies have shown that this...
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Target Advancement Program, 2022Assessing the Ability of Neuronal Modulators to Treat or Modify the Motor Symptoms of Parkinson’s Disease
Study Rationale: The dopamine-producing cells that are lost in Parkinson’s disease (PD) express a unique type of cell-surface protein called the M5 muscarinic acetylcholine receptor. The presence of...
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Expanding Biological Understanding of Parkinson's Disease, 2022Investigation of the Role of PINK1 in Regulating Immune Signaling in Mitochondria
Study Rationale: Evidence is accumulating that the Parkin and PINK1, gene products whose activities are altered in Parkinson’s disease (PD), play a role in immune signaling. We previously identified a...
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Therapeutic Pipeline Program, 2022Developing an Assay to Identify Glucocerebrosidase-enhancing Chaperones for the Treatment of Parkinson’s Disease
Study Rationale: Discovering genes associated with Parkinson’s disease (PD) facilitates the design of new treatment strategies for this disorder. Mutations in the glucocerebrosidase gene (GBA1) are...
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Research Grant, 2022Shoring Up a Medical Chemistry Approach to Treating Parkinson’s Disease: The Bridge Initiative
Study Rationale: The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of biological pathways often disrupted in the disorder. This connection makes...
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Proof-of-Concept Testing of PD Therapeutics, 2022Using Data from the LEAPS Project to Improve the Accuracy of Assays that Measure Alpha-synuclein
Study Rationale: The scientific and clinical research community working on Parkinson’s disease (PD) is in need of biomarkers to facilitate the monitoring of disease progression and efficacy of...
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Our funding programs support basic, translational and clinical research from academia and industry.