The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Using Data from the LEAPS Project to Improve the Accuracy of Assays that Measure Alpha-synuclein
Study Rationale: The scientific and clinical research community working on Parkinson’s disease (PD) is in need of biomarkers to facilitate the monitoring of disease progression and efficacy of...
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Expanding Biological Understanding of Parkinson's Disease, 2022Characterization of the Contributions of Alpha-synuclein and Tau Aggregation in a Preclinical Model of Parkinson’s Disease Progression
Study Rationale: Motor difficulties are not the only symptoms experienced by people with Parkinson’s disease (PD); up to 80% eventually develop dementia. This progression to dementia is associated...
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Target Advancement Program, 2022Mining for Protein Aberrations in Parkinson’s Disease Using Large-Scale Protein Databases
Study Rationale: Deficient clearance of misfolded alpha-synuclein aggregates contributes to the pathology of Parkinson’s disease (PD). But broader disturbances in proteostasis—the balanced production...
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Parkinson’s Pathway Molecular Data Analysis Program, 2022Resolution of Parkinson-associated Loci and Creation of Predictive Models Using Multi-omic Data Analyses
Study Rationale: Genetic studies have allowed us to understand better the genetic risk of suffering from Parkinson’s disease. However, for most of the findings we do not know the biological meaning or...
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Cellular Phenotyping in Human iPSCS from the PPMI Cohort, 2022Simultaneous Profiling of Gene Expression Patterns from Pooled Cell Samples of Large Parkinson’s Disease Cohorts
Study Rationale: The PPMI study provides a repository of stem cells that can be converted into dopamine-producing neurons and microglia for modeling Parkinson’s disease (PD). Maintaining these cells...
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Expanding Biological Understanding of Parkinson's Disease, 2022Gaining Mechanistic Insights into PINK1 Genetic Variants
Study Rationale: Mutations in the Parkin and PINK1 genes cause early-onset familial Parkinson's disease (PD). These genes produce enzymes that function together to degrade damaged mitochondria, the...
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Our funding programs support basic, translational and clinical research from academia and industry.