The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Expanding Biological Understanding of Parkinson's Disease, 2022Gaining Mechanistic Insights into PINK1 Genetic Variants
Study Rationale: Mutations in the Parkin and PINK1 genes cause early-onset familial Parkinson's disease (PD). These genes produce enzymes that function together to degrade damaged mitochondria, the...
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Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Validation of RRx-001 as a Novel Disease-modifying Therapeutic for Parkinson's Disease
Study Rationale: Our project will test the effectiveness of a new treatment for Parkinson’s disease (PD) called RRx-001. We believe this drug could be beneficial in PD by blocking inflammasome...
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Target Advancement Program, 2022Targeting GPR43 in T-cells as a Potential Treatment for Parkinson’s Disease
Study Rationale: Parkinson's disease involves the generation of pathogenic proteins in the neurons, which trigger an immune response driven by inflammatory lymphocytes that infiltrate the brain and...
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Expanding Biological Understanding of Parkinson's Disease, 2022Evaluating the Role of Miro1 in Mitochondrial Quality Control in Parkinson’s Disease
Study Rationale: Growing evidence suggests that dysfunction is linked to Parkinson’s disease (PD). These structures supply cells with energy, but must be eliminated when they become damaged — a...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Therapeutic Efficacy of IC 100 in Small Models
Study Rationale: Parkinson’s disease (PD) is characterized by the loss of neurons in the brain. Despite available treatments, no approved therapy can slow disease progression. Data in humans and small...
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Fall 2021 RFP: Outcome Measures, 2022Pet Imaging to Determine Regional and Temporal Trajectories of Reactive Astrocytosis in Parkinson’s Disease
Study Rationale: Neuroinflammation is a known process accompanying Parkinson’s disease (PD) neuropathology. During this process, specific brain cell populations become chronically activated, including...
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Our funding programs support basic, translational and clinical research from academia and industry.