The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Kinase Activity-mediated Changes in LRRK2-Parkinson's and Sporadic Parkinson's Cells and Rab Protein Function
Promising Outcomes of Original Grant:
Our previous studies have demonstrated deficits in cohesion, positioning, and polarity (important characteristics of cells that help regulate function) in... -
Research Grant, 2016Multi-center Study of EEG Biomarkers for Alpha-synucleinopathy Diagnosis and Prognosis Decision Support Tools Using Machine Learning
Promising Outcomes of Original Grant:
In our original study, the aim was to develop computational tools based on signal processing and machine learning for the diagnosis and prediction of Parkinson's... -
Target Advancement Program, 2016Insights into LRRK2 Kinase Inhibitors
Study Rationale:
Mutations in LRRK2 cause an inherited form of Parkinson's disease (PD), and variations in LRRK2 can increase disease risk, indicating that the protein is key in the entire PD disease... -
Target Advancement Program, 2016Targeting the Transcriptional Regulator of Autophagy LMX1B for Parkinson's Disease Therapeutic Development
Study Rationale:
LMX1B is a transcription factor that plays an essential role in the development of dopaminergic neurons. We have recently described a new role for LMX1B in dopaminergic neurons as a... -
Rapid Response Innovation Awards, 2014Neuroimaging Carriers of the Alpha-synuclein E46K Mutation as a Model of Idiopathic Lewy Body Disease
Study Rationale:
In 2004 our group described, for the first time in literature, the E46K mutation of the alpha-synuclein gene in a family from the Basque region of Spain. The rare E46K mutation is... -
Research Grant, 2014Retinal Pathology in Parkinson’s Disease: Implications for Vision and Biomarkers
Study Rationale:
Vision problems are not what most of us think of when we think of Parkinson’s disease (PD), but there are some physical changes in the retina of people with PD...
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