The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-synuclein Pathology, 2014Characterization and Validation of Disease-specific Alpha-synuclein Species in Cerebrospinal Fluid
Study Rationale:
The protein alpha-synuclein plays a major role in Parkinson’s disease (PD). Quantification of alpha-synuclein in biological fluids (e.g., cerebrospinal fluid) could... -
LRRK2 Challenge, 2013LRRK2 and Vitamin D3 Metabolism
Objective/Rationale:
The LRRK2 kinase enzyme is mutated in some patients with Parkinson’s disease (PD). Coincidentally, the kinase is widely expressed in most organs of the body. We... -
Clinical Intervention Awards, 2013Dipraglurant for Levodopa-Induced Dyskinesia Pre-phase IIB Studies
Study Rationale:
Dipraglurant is a modulator of the metabotropic glutamate receptor 5 (mGluR5). Blockade of this receptor has been shown to have anti-parkinsonian and anti-dyskinetic... -
MJFF Research Grant, 2012Novel PD Tools: Generation of Posttranslationally Modified Alpha-synuclein
Objective/Rationale:
There is increasing evidence linking specific posttranslational modification (folding, cutting, etc. of proteins before maturation) and alpha-synuclein aggregation... -
MJFF Research Grant, 2011Generation of Synthetic Alpha-synuclein for the PD Research Community
Objective/Rationale:
Despite increasing evidence linking specific modifications to alpha-synuclein (alpha-syn), alpha-synuclein aggregation, and Lewy body (LB) formation, little is still known... -
LRRK2 Challenge, 2011Regulation of LRRK2 Activity by Nitric Oxide-Mediated Protein S-Nitrosylation
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial Parkinson’s disease (PD). Familial mutations can influence the GTPase or kinase activity of LRRK2 which may be...
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Our funding programs support basic, translational and clinical research from academia and industry.