The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Cell Line, 2002Establishing stable lines of human nigral dopaminergic progenitor cells
We intend to develop lines of clonal, stable and self-renewing human dopamine-producing neuronal progenitor cells. These will be derived from the part of the midbrain that gives rise to dopamine...
-
Cell Line, 2002Dopamine Neurons Derived from Human ES Cells
Embryonic stem (ES) cells proliferate extensively, and preliminary data show that animal ES cells can be manipulated to generate highly enriched populations of dopamine neurons that express genes...
-
Cell Line, 2002Unlimited Numbers of Purified Midbrain Dopamine Neurons from Human Embryonic Stem Cells
The fact that dopamine (DA) cells are lost specifically but other nerve cells are still intact makes Parkinson's disease (PD) uniquely amenable to cell replacement therapy. Early attempts have...
-
Cell Line, 2002Banking of and Dopamine Neuronal Production from Human Neural Stem Cells
Transplantation of dopamine neurons in Parkinson's disease has resulted in significant improvements for some patients. However, large-scale clinical trials are impossible due to the technical and...
-
Cell Line, 2002Generation of Transplantable Dopamine Neurons from Human Emryonic Stem Cells
The focal nature of neuronal loss suggests that cell replacement therapy may be suitable for Parkinson's disease. Indeed, transplanted fetal midbrain cells survive in some Parkinson's patients for...
-
The Role of Protein Degradation in Parkinson's Disease, 2002RNAi Screening and Analysis of Factors Influencing ER-Associated Degradation and Alpha-Synuclein Aggregation in C. elegans
Failure of proteins to adopt their proper structure is a common cause of cellular dysfunction. Quality control mechanisms within cells serve to promote accurate protein folding. Breakdown of these...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.