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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Access to Data & Biospecimens, 2018
    Rapid and Ultra-sensitive Quantitation of Disease-associated and Synuclein Seeds in Brain and Cerebrospinal Fluid by Syn RT-QuIC

    Study Rationale:                   

    The diagnosis and treatment of Parkinson’s disease (PD) would be aided by the availability of direct and highly sensitive tests for the abnormal clusters of the...

  • Improved Biomarkers and Clinical Outcome Measures, 2017
    Using Automatic Acoustic Speech Analysis and REM Sleep Behavior Disorder to Detect Individuals at High Risk of Parkinson's Disease and Other Alpha-synucleinopathies

    Study Rationale:
    Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to the progression of neurologic diseases. The aim of this project is to...

  • Oligomeric & pS129 Assay LEAPS, 2017
    Quantification of S129 Phosphorylated Alpha-synuclein Using the AlphaLISA® Immunoassay Platform

    Study Rationale:
    The alpha-synuclein protein is a key player in Parkinson’s disease (PD). Our ability to understand how this protein impacts the health of neurons in the brain is directly related to...

  • Improved Biomarkers and Clinical Outcome Measures, 2017
    Developing Biosignatures of Parkinson's Disease Using Sense of Smell

    Study Rationale:
    Recent reports of "super-smelling powers" published in The Lancet Neurology has triggered the idea of a specific "musky" scent in the sebum, an oily skin secretion, of those with...

  • LRRK2 Biology Consortium, 2017
    Kinase Activity-mediated Changes in LRRK2-Parkinson's and Sporadic Parkinson's Cells and Rab Protein Function

    Promising Outcomes of Original Grant:
    Our previous studies have demonstrated deficits in cohesion, positioning, and polarity (important characteristics of cells that help regulate function) in...

  • Research Grant, 2017
    Inflammation in Parkinson's Disease

    Study Rationale:

    The contribution of inflammation to Parkinson's disease (PD) is increasingly being recognized. However, the stage of the disease in which inflammation is prevalent and/or important...

Two female doctors talking in the lab.

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