The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2015Nuclear Magnetic Resonance Analysis to Support Development of Alpha-Synuclein Imaging Agents
Study Rationale:
The Michael J. Fox Foundation Imaging Consortium has identified several promising compounds that bind specifically to alpha-synuclein fibrils, the clumps of protein that accumulate in... -
Target Validation, 2015Transcription Factors as Key Targets to Regulate The Selective Vulnerability of Dopamine Neurons
Study Rationale:
Why specific subsets of brain cells such as those containing the chemical messenger dopamine are particularly vulnerable and degenerate is one of the central... -
Research Grant, 2015CAPTURE-PD: Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease
Study Rationale:
Parkinson’s disease is a progressive neurodegenerative disorder that does not only affect movement but also the autonomic nervous system. Since most people start... -
Research Grant Supplement, 2015Hit-to-Lead Optimization of Parkin Activators through Structure-Function Analyses
Objective/Rationale:
This project aims to develop potent small molecule activators of Parkin, which is mutated in some forms of familial Parkinson’s disease and might also be inactivated... -
Research Grant, 2015Amelioration of Mitochondrial Oxidant Stress by Isradipine and Rasagiline
Study Rationale:
The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons. One potential cause of this degeneration is calcium... -
Biomarker Development, 2015Biomarker and DNA Samples Collection Add-on Study to the Phase III Trial of Isradipine
Study Rationale:
Isradipine, an FDA-approved agent for treatment of high blood pressure, was shown to be have neuroprotective benefit in models of Parkinson’s disease (PD). A recently completed Phase...
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Our funding programs support basic, translational and clinical research from academia and industry.