The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2014Anti-dyskinetic Activity of the Selective 5-HT1A Agonist NLX-112: Behavioral and Microdialysis Studies
Promising Outcomes of Original Grant:
These researchers are investigating the activity of novel drugs that potently activate serotonin 5-HT1A receptors. Targeting this receptor subtype is an attractive... -
Access to Data and Biospecimens, 2014Effect of LRRK2 Mutations on PD-associated Inflammation
Objective/Rationale:
Increased inflammation is associated with the progression and possibly even onset of Parkinson’s disease (PD). Mutations in the LRRK2 gene are also associated with PD, and recent... -
Access to Data and Biospecimens, 2014Defining Non-motor Phenotypes in Parkinson’s Disease and Novel Strategies for Diagnosis
Objective/Rationale:
Although Parkinson’s disease (PD) is diagnosed as a movement disorder, motor deficits are preceded by non-motor features including cognitive, cardiovascular, gastrointestinal... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Age-related Alterations in LRRK2 Expression and Function in Immune Cells and Risk for Idiopathic Parkinson's Disease
Objective/Rationale:
The LRRK2 protein is highly expressed in immune cells, but its function is unknown and may change as the immune system changes with aging and environmental exposures, the largest... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Non-dopaminergic Systems in the Evolution of LRRK2 Parkinsonism
Objective/Rationale:
Researchers have previously demonstrated that the pattern and evolution of progressive changes in the dopamine system in Parkinson’s disease (PD) associated with LRRK2 mutations... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2014Activation of Microglial LRRK2 by Alpha-synuclein: LRRK2 Pathogenesis in Idiopathic PD
Objective/Rationale:
Alpha-synuclein is a protein that plays an important role in all forms of Parkinson’s disease (PD). Recent data demonstrate that brain cells can secrete alpha-synuclein and that...
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Our funding programs support basic, translational and clinical research from academia and industry.