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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Alpha-Synuclein Imaging, 2011
    Consortium to Develop an Alpha-synuclein Imaging Agent

    Objective/Rationale: 
    The ultimate goal of this project is develop a positron emission tomography (PET) radiotracer to image the distribution of alpha-synuclein in the brain. Alpha-synuclein imaging...

  • Research Grant, 2011
    Testing Effects of Improved Levodopa Delivery with Dexterity and Gait Objective Measures

    Objective/Rationale: 
    The objective of this project is to develop an extended-release capsule of levodopa/carbidopa (IPX066) that will result in constant blood levels of levodopa compared to current...

  • Repositioning Drugs for PD, 2011
    Duloxetine Hydrochloride as a Novel Neuroprotective Treatment for Parkinson's Disease

    Objective/Rationale: 
    In Parkinson’s disease (PD) dopaminergic neurons in the midbrain region substantia nigra pars compacta die. There is currently no treatment available that prevents this cell death...

  • Repositioning Drugs for PD, 2011
    Evaluation of a Specific DAT Inhibitor in Pre-clinical Models of Parkinson's Disease

    Objective/Rationale: 
    MLR-1017 is a psychostimulant drug used clinically for a variety of neuropsychiatric and other applications, but has never been tested in Parkinson’s disease (PD). Levodopa is a...

  • Antibody Comparison, 2011
    Antibody Testing in Postmortem Human Brain

    Objective/Rationale: 
    Mutations in the gene for LRRK2 are the most common genetic cause for Parkinson’s disease (PD) and therefore the LRRK2 protein appears to be important for normal brain function...

  • Research Grant, 2011
    LRRK2 Antibody Comparison 2011

    Objective/Rationale: 
    LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some...

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