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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Dopamine Toxicity Hypothesis: Interaction with Alpha-Synuclein in the Intact Brain

    Objective/Rationale: 
    Identification of mutations in the alpha-synuclein gene in a familial form of Parkinson’s disease, then the demonstration of alpha-synuclein containing pathological aggregations...

  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Elucidating the Role of Phosphorylation in modulating alpha-synuclein aggregation and toxicity in Parkinson's disease and related disorders

    Objective/Rationale:
    Chemical changes in the protein alpha-synuclein, such as the binding of phosphate groups (phosphorylation), are characteristic of Parkinson's disease  and related alpha...

  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Impact of Post-Translational Modifications on the Neurotoxicity of Alpha-Synuclein in Parkinson's Disease

    Objective/Rationale:

    The loss of neurons in the brains of Parkinson’s disease patients may be caused by harmful clusters or ‘aggregates’ of alpha-synuclein, an abundant protein in the central nervous...

  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Genetic Dissection of LRRK2 Domains Critical For Pathogenesis via BAC Transgenic Approach

    Objective/Rationale:
    Mutations in the LRRK2 gene are responsible for certain types of familial Parkinson’s disease. The protein product of the LRRK2 gene has a complex structure and to date, research...

  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Delivery of Kinase-Modified LRRK2 to Dopaminergic Neurons Using High-Capacity Viral Vectors

    Objective/Rationale:
    Mutations in the LRRK2 gene unambiguously associate with the development of late-onset Parkinson’s disease that mimics clinical and neurochemical features typical of the disease...

  • Critical Challenges in PD: Translating Genetic Findings Into, 2007
    Using BAC Transgenic Mice to Determine Causative Role of LRRK2 Kinase Activity in PD Pathogenesis

    Objective/Rationale: 
    Emerging evidence has implicated kinase activity of LRRK2, the PD. The objective of this project is to use novel animal models to determine whether enhanced LRRK2 kinase activity...

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