The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2006Dopaminergic Neurons Derived from Human Embryonic Stem Cells for Transplantation Therapy in Parkinson's Disease
One of the promising potential treatments for halting the progress of Parkinson's disease and restoring lost function is cell replacement using dopamine producing neurons derived from human embryonic...
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Development of Progressive Pre-clinical Models of PD, 2006Generation of Transgenic Mice with Selective and Progressive Loss of Nigrostriatal Dopaminergic Neurons
Mutations in the alpha-synuclein gene are responsible for rare, dominantly inherited forms of familial Parkinson's disease, designated PARK1 and PARK4. Furthermore, alpha-synuclein is also the major...
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Development of Progressive Pre-clinical Models of PD, 2006P1 Artificial Chromosome Transgenic Mice as models for Progressive Parkinson Disease
Although most cases of Parkinson's disease occur without a family history, there are examples of highly hereditary forms of the disease. One rare form of hereditary PD is caused by alterations in a...
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Development of Progressive Pre-clinical Models of PD, 2006LRRK2 and PD Genetic Pre-clinical Models
The cause of Parkinson's in most patients is unknown, but in a small percentage of cases (three to five percent), mutation in a specific gene is causal. Several genes have been conclusively linked to...
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Development of Progressive Pre-clinical Models of PD, 2006Inflammatory Stimuli as 'Second-Hit' Triggers for Development of Progressive Nigral Degeneration
Parkin and DJ-1 knockout mice model the recessively inherited loss-of-function mutations in these genes that cause human parkinsonism. Despite significant nigrostriatal dysfunction in both knockout...
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Development of Progressive Pre-clinical Models of PD, 2006The PD Pre-Clinical Model: A Progressive Model of Parkinson's Disease with Key Pathology and Behavior Caused by Targeting Mitochondrial Function in Dopamine Neurons
Recent research suggests that there can be genetic causes of Parkinson's disease. In several forms of the disease, these genetic disturbances appear to compromise function of the cells' energy...
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Our funding programs support basic, translational and clinical research from academia and industry.