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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Generation and Characterization of Mice with Inducible and Cell-Type Specific Interruption ofGDNF Signaling

    The primary goal of this proposal is the generation of two powerful and innovative conditional mouse knockout strains to interrupt GDNF signaling. We propose to conditionally knock out the GDNF...

  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Small Molecules That Promote Regeneration of Dopaminergic Neurons from Human Neural Stem Cells

    For a better understanding of the signaling pathways that instruct neural precursor cells to differentiate into dopaminergic (DA) neurons (which are lost in the brain of Parkinson's Disease patients)...

  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Role of Pitx3 in the Development of Midbrain DA Neurons

    Parkinson's disease (PD), one of the most common neurodegenerative diseases, is caused by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Molecular...

  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Studies on Endogenous Neurogenesis in the Adult Mammalian Substantia Nigra

    We have published evidence for a slow, endogenous generation of new dopaminergic nerve cells in the adult mouse midbrain, i.e. the nerve cell type lost in Parkinson's disease. (PNAS 100, 7925-7930...

  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Role of Neural Precursor Cells of Ventricular Wall Origin in Endogenous Plasticity in Animal Models of PD

    Stem cells attract much interest in research on neurodegenerative disorders, because it might become possible to replace lost neurons. Because success and feasibility of transplantation approaches are...

  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Identification of Axon Guidance Molecules Relevant to the Midbrain Dopaminergic System

    In Parkinson's patients a substantial number of dopaminergic neurons necessary for proper motor control have died, leading to dyskinesias that make it difficult to walk and talk. A promising approach...

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