The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2003Development of the Midbrain Dopaminergic Pathways
Parkinson's disease is a result of degeneration of the midbrain dopaminergic (DA) neurons. In the treatment of Parkinson's disease, replacing lost neurons is a promising therapy. However, the progress...
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Community Fast Track, 2003In vivo investigation of DJ-1 function in DJ-1 knockout mice
Two genetic mutations in the DJ-1 gene have been identified earlier this year that can cause early-onset Parkinson's disease. Since both mutations are believed to cause loss of function of the DJ-1...
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The Role of Inflammation in Parkinson's Disease, 2003The Role of TNF-Mediated Dopaminergic Neurotoxicity in Parkinson's Disease: Novel Anti-TNF Biologics as Biochemical Tools and New Therapeutic Agents
Loss of dopamine-producing neurons is a hallmark of Parkinson's disease and inflammation-driven oxidative stress is believed to play a significant role in this neurodegenerative process.
Strong...
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Community Fast Track, 2003Osteopontin as a regulator of the inflammatory response to nigral celldegeneration
The cause of nerve cell death in the substantia nigra in Parkinson's disease remains unknown. However, one feature of the degenerative process is the onset of inflammation in this brain region due to...
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Community Fast Track, 2003Role of Delta FosB in the Development of Levodopa-induced Dyskinesia
The goal of this project is to study mechanisms responsible for the dyskinesia side effect of levodopa seen in patients with Parkinson's disease. The proposed experiments focus on a protein, called...
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Community Fast Track, 2003NBD Peptides in MPTP Pre-clinical Model
Understanding the mechanism of the disease process of Parkinson's dis and development of effective neuroprotective therapeutic approach to halt the disease progression are of paramount importance. It...
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Our funding programs support basic, translational and clinical research from academia and industry.