The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Cognitive Deficits and Mood Disorders in Parkinson's Disease, 2008Cognitive Decline in Parkinson's Disease
Objective/Rationale:
There are many studies on cognitive and behavioral alterations in Parkinson’s disease, but each of these investigations brought only a small piece of a large puzzle. Consequently... -
Program-non-specific Funding, 2008Validation of TorsinA as a Target for PD Therapy in Mammalian Models
Objective/Rationale:
Mutations in the protein torsinA cause a hereditary form of dystonia. While the normal function of torsinA is not entirely clear, it is thought to be a “chaperone,” a molecule... -
Rapid Response Innovation Awards, 2008Exploring a Novel Pathogenetic Mechanism in Parkinson's Disease
Objective/Rationale:
We recently reported that neuropathological changes gradually propagate from Parkinson disease patients’ brains to grafted neurons. Over one decade after graft surgery, we found... -
Rapid Response Innovation Awards, 2008Expression, Purification and Crystallization of the LRRK2 Kinase
Objective/Rationale:
Mutations in the gene encoding Leucine Rich Repeat Kinase 2 (LRRK2) are found in a substantial number of patients with familial or sporadic forms of Parkinson’s disease, and it has... -
Rapid Response Innovation Awards, 2008Evaluation of LRRK2 Inhibitors in the LRRK2 Drosophila PD Model
Objective/Rationale:
Biochemical evidence suggests that aberrant GTPase and kinase activities are linked to disease causing mutations in LRRK2, and may be at the basis of neuronal toxicity and... -
Rapid Response Innovation Awards, 2008Bee Venom as a Neuroprotective Agent in Parkinson's Disease
Objective/Rationale:
Based on a serendipitous obsrevation in one patient with Parkinson’s disease (PD), resaerchers wish to verify, in a pre-clinical model of the disease, whether bee venom and one of...
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