The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2011Regulatory T Cells as Modulators of Microglia's Inflammatory Response
Objective/Rationale:
Evidence in humans and in research models support a role for the immune system in the progression of Parkinson's disease. Local brain immune cells, called microglia, as well as... -
Clinical Intervention Awards, 2011First-in-human Trial to Assess the Safety and Tolerability of PD01, the First Alpha-synuclein-based AFFITOPE® Parkinson's Vaccine
Objective/Rationale:
Parkinson’s disease (PD) is characterized by the presence of protein aggregates called Lewy bodies, with a major component of the protein alpha-synuclein. This fact and... -
Rapid Response Innovation Awards, 2011Drug Rescue of PINK1 Kinase Activity - A New Therapeutic Modality For Treating PD
Objective/Rationale:
Many genetic disorders are caused by the loss of a functional protein which protects cells from disease. These disorders are difficult to treat with drugs because most drugs... -
Target Validation, 2011Targeting of Alpha-synuclein and SNARE Complex Dysfunction to Restore Synaptic Dopamine Release in a Model of Parkinson Disease Pathology
Objective/Rationale:
Research data has recently indicated that pathology in Parkinson’s disease (PD) starts at the synapse, the part of the neurons where the release of dopamine occurs, dysfunction of... -
MJFF Research Grant, 2011Identification of a Novel Calcium Selective Antagonist for Neuroprotection in PD
Objective/Rationale:
Nothing is known to slow or stop the progression of Parkinson’s disease. Our work and that of others suggests that antagonism of calcium channels having a Cav1.3 pore forming... -
LRRK2, 201114-3-3s as Regulators of LRRK2 Toxicity
Objective/Rationale:
This project will evaluate the functional consequences of the interaction between 14-3-3 proteins and LRRK2. 14-3-3 proteins play a crucial role in inhibiting cell death pathways...
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Our funding programs support basic, translational and clinical research from academia and industry.