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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2018
    Searching for Signs of Parkinson's Disease in the Eye

    Study Rationale:
    Alpha-synuclein is a protein that clumps in the brains of people with Parkinson's disease (PD). These clumps have also been found in the brain and, recently, the retina -- the back of...

  • Target Advancement Program, 2018
    The Role of Lysosomal Lipid Metabolism in Parkinson's Disease

    Study Rationale:
    Lysosomes -- tiny bubbles inside the cell responsible for disposing of its waste -- don't work as they should in brain cells of people with Parkinson's disease (PD). Lysosomes are...

  • Mitochondrial Biomarkers Program, 2018
    Mitochondrial DNA Damage in a Pesticide-exposed Cohort

    Study Rationale:
    Environmental poisons may cause or contribute to some cases of Parkinson’s disease (PD). Mitochondrial impairment is seen in all forms of PD. Some environmental exposures, such as...

  • Improved Biomarkers and Clinical Outcome Measures, 2018
    Cognitive-driven Activities of Daily Living Impairment as a Predictor for Parkinson's Disease Dementia

    Study Rationale:
    Mild cognitive impairment in Parkinson's disease (PD-MCI) is the highest risk factor for Parkinson's disease dementia (PDD). The core feature for differentiating PDD from PD-MCI is...

  • Therapeutic Pipeline Program, 2018
    The PERSPECTIVE study: Personalized Speech Therapy for Active Conversation

    Study Rationale:
    Many people with Parkinson's disease have speech problems, which can be overcome by instructing patients to intentionally speak louder. However, to use this technique in daily life...

  • Inflammation Biomarkers Program, 2018
    Studying Age-related Chronic Inflammation in Parkinson's Disease

    Study Rationale:
    Aging increases the risk of Parkinson's disease (PD), making the disease more likely to occur at an older age. It is unclear how biological changes that accompany normal aging are...

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