The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2016Small-molecule Inhibitor to Stop Alpha-synuclein Spread for the Treatment of Parkinson's Disease
Study Rationale:
The hypothesis that misfolded alpha-synuclein (a protein associated with Parkinson's) aggregates (clumps) move from neuron-to-neuron is gaining widespread acceptance as a central... -
Research Grant, 2016Planning Phase for a Phase IIa Study of Nilotinib in People with Parkinson's Disease
Study Rationale:
Nilotinib, a drug approved for chronic myelogenous leukemia, inhibits the protein c-Abl. Higher brain levels of c-Abl are associated with Parkinson's disease (PD), and laboratory...
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Therapeutic Pipeline Program, 2016Small Molecule Inhibitors of C-Abl for Parkinson's Disease Modification
Study Rationale:
Abelson tyrosine kinase (c-Abl) is believed to drive the deleterious events leading to loss of dopamine neurons in people with Parkinson's disease. This project will identify small... -
Research Grant, 2016Antibody Development for Modified Parkin Proteins Identified in the Human Brain
Study Rationale:
The PARK2 gene encodes the Parkin protein. It is one of three genes that protect from young-onset Parkinson disease (PD); in Parkin's absence, symptoms and signs usually begin before... -
Target Advancement Program, 2016Validation of the 18kDa Translocator Protein as a Novel Immunomodulator to Slow Progression in Parkinson's Disease
Study Rationale:
The immune system in the brain has two distinct modes: mode one is fighting infection and mode two is repairing injured nerve cells. In Parkinson's disease (PD), we think that the... -
Research Grant, 2016Effect of Parkin on Mitochondrial Protein Expression
Study Rationale:
Mutations in the gene encoding the protein parkin cause an inherited form of Parkinson's disease (PD). Parkin plays a neuroprotective role in response to stresses that affect the...
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Our funding programs support basic, translational and clinical research from academia and industry.