The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2015Anti-inflammatory Role of Activin-A in Protection against Alpha-synuclein-mediated Pathology
Objective/Rationale:
Neuroinflammation is essential for the pathogenesis and progressionof Parkinson’s disease (PD); therefore, the identification of immunosuppressive agents that can... -
Improved Biomarkers and Clinical Outcome Measures, 2015Eye Tracking as a Biomarker for Manifest and Prodromal Parkinson’s Disease
Study Rationale:
Over the past 14 years, we have utilized sophisticated commercial eye movement monitoring equipment to collect data from over 3300 participants. Our work aims to... -
Therapeutic Pipeline Program, 2015Alpha4Beta2 Nicotinic Agonist for Treatment of L-Dopa Refractory Gait and Balance Disorders in Parkinson Disease
Study Rationale:
Gait and balance problems, particularly falls, are common and disabling symptoms in Parkinson disease (PD), and do not improve markedly with existing treatments. Studies have indicated... -
Target Validation, 2015Validating the Neuroprotective Enzyme ACMSD as a Novel Therapeutic Target in Parkinson's Disease by Viral Vector-Mediated Overexpression
Study Rationale:
A number of genetic studies have linked variation in the enzyme aminocarboxy-muconate semialdehyde decarboxylase (ACMSD) with a risk for Parkinson’s... -
Target Validation, 2015Targeting the NLRP3 Inflammasome in Models of Parkinson's Disease
Objective/Rationale:
Chronic inflammation within the brain is emerging as a possible driver in the progression of Parkinson’s disease (PD). Inflammasomes are protein complexes that... -
Research Grant, 2015VPAC2 Agonists Neuroprotective and Anti-inflammatory Effects in Parkinson's Disease
Study Rationale:
The adaptive and innate immune responses play intricate roles in modulating neuroinflammation and may be harnessed for neuroprotection from Parkinson’s disease. We...
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Our funding programs support basic, translational and clinical research from academia and industry.