The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2015NLRP3 Inflammasome in Parkinson's Disease
Objective/Rationale:
The goal of this proposal is to validate the NLRP3 inflammasome as a therapeutic target in Parkinson’s disease. Unlike circulating inflammatory mediators whose complex... -
Research Grant, 2015Cell-to-Cell Transport of Alpha-Synuclein
Study Rationale:
In Parkinson’s disease, the protein alpha-synuclein changes shape, and we think it transfers around the brain. We want to see if we can recreate this in non-human... -
Research Grant, 2015Selective mGluR3 Positive Allosteric Modulators as Neuroprotective Agents for Parkinson's Disease Supplement
Study Rationale:
mGluR3 is a novel target leading to neuroprotection through production of neurotrophic factors. We have recently demonstrated that selective mGluR3 positive... -
Research Grant, 2015Pre-clinical Evaluation of Neuroprotective Small Molecule Erythropoietin Receptor Agonists in the Treatment of Parkinson’s Disease Supplement
Study Rationale:
STATegics has discovered small molecules that selectively activate the tissue-protective erythropoietin (EPO) receptor, but not the EPO receptor that plays a role in... -
Therapeutic Pipeline Program, 2015GAITPARK_ATLAS: Finding New Targets to Treat Gait and Balance Disorders in Parkinson’s Disease
Study Rationale:
Gait and balance disorders are the primary motor disability in advanced Parkinson’s disease (PD). These disorders arise in part due to dysfunction of the lateral... -
Research Grant Supplement, 2015Parc (a Parkin-related E3 ligase): Functions in Neuronal Survival and Parkinson’s Disease Supplement
Promising Outcomes of Original Grant:
Our research had identified a Parkin-related protein, called Parc, to be important for neuronal survival in situations of mitochondrial injury. Specifically, we...
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Our funding programs support basic, translational and clinical research from academia and industry.