The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2014Screening Assays for Restored Protein Trafficking
Study Rationale:
Protein trafficking is the process by which proteins are transported from where they’re made to where they’re needed inside cells. Defects in trafficking cause proteins to accumulate... -
Rapid Response Innovation Awards, 2014Alpha-synuclein Knock-down Peptides for Neuroprotection and Reversal of Pathology in a Model of Parkinson’s Disease
Study Rationale:
Protein misfolding and aggregation is likely to be a central mechanism in the neurodegenerative changes seen in Parkinson’s disease (PD). The Canadian partner in this project has... -
Research Grant, 2014Imaging Neuroinflammation in LRRK2 Models of Parkinson’s Disease
Objective/Rationale:
The mechanisms for the initiation and progression of the loss of dopamine (DA) neurons in Parkinson’s disease (PD) are still largely unknown. Increasing evidence indicates that... -
LRRK2 LEAPS, 2014Targeting Retromer Dysfunction: A Convergent Mechanism in Familial and Sporadic Parkinson’s Disease
Study Rationale:
Our goal is to understand how mutations in the gene LRRK2 can drive Parkinson’s disease (PD) risk. Our previous studies of neurons with mutant LRRK2 kinase have... -
LRRK2 Challenge, 2014Inhibition of PKA as a Mechanism to Reverse LRRK2 Mutation-induced Parkinson's Disease
Study Rationale:
Unraveling the role of LRRK2 mutations in disease remains a critical question in Parkinson’s research. The high expression of LRRK2 protein in part of the brain called the striatum... -
Target Validation, 20145-alpha-reductase Inhibition for the Treatment of Levodopa-induced Dyskinesia
Study Rationale:
Although the cause of levodopa-induced dyskinesia is still unclear, these motor complications appear to be due to abnormal dopamine transmission in the brain. Compelling evidence has...
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Our funding programs support basic, translational and clinical research from academia and industry.