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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2014
    Inhibition of a Dopamine Receptor in Lymphocytes as a Treatment for Parkinson's Disease

    Objective/Rationale:             
    Emerging evidence has shown that lymphocytes, a kind of immune system cells, play a fundamental role in the development and progression of Parkinson's diseases. Our...

  • Research Grant, 2014
    Accelerated Pre-clinical Development of a Novel and Specific Alpha-synuclein Tracer

    Objective/Rationale:
    Biomarkers that can communicate the underlying pathology of Parkinson’s disease (PD) in living patients would be invaluable for diagnosis and for evaluation of disease-modifying...

  • Cognition Biomarkers, 2014
    miRNA Markers of Cognition

    Objective/Rationale:
    In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs...

  • Parkin Biology, 2014
    Role of Parkin in Innate Immunity

    Objective/Rationale:
    The protein Parkin contributes to the elimination of damaged mitochondria by a process called mitophagy. Prior research has shown that silencing Parkin gene affects innate immunity...

  • Rapid Response Innovation Awards, 2014
    The Microbiome in Parkinson's Disease: Role as a Potential Biomarker and Relation to Disease Progression

    Promising Outcomes of Original Grant:
    In their previous study these researchers investigated whether the abundance of different microbes in the gut differs between Parkinson’s disease (PD) patients and...

  • Rapid Response Innovation Awards, 2014
    Parc (a Parkin-related E3 Ligase): Functions in Neuronal Survival and Parkinson’s Disease

    Objective/Rationale:
    Parkinson’s disease (PD) is frequently associated with mutations in the gene that encodes Parkin, a protein that detects and degrades dysfunctional mitochondria. While removing...

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