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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2013
    Discovery of EEG Biomarkers for Parkinson's Disease and Lewy Body Dementia

    Objective/Rationale:             
    We aim to develop a non-invasive, low-cost pre-clinical biomarker for synucleinopathies such as Parkinson’s disease (PD) or Lewy body dementia (LBD), which will have...

  • Research Grant, 2013
    DPI-289, a Novel Bi-Functional Delta Agonist / Mu Antagonist (DAMA) as a Therapy for Parkinson's Disease

    Objective/Rationale:
    Eboo Pharmaceuticals Inc. is developing an approach to treating Parkinson’s disease (PD) via a delta agonist/mu antagonist (DAMA) mechanism expected to provide efficacious and well...

  • Research Grant, 2013
    Preferential Targeting of Subpopulations of 5-HT1A Receptors: Microdialysis Study

    Promising Outcomes of Original Grant:
    Researchers investigated the effects of serotonin 5-HT1A biased agonists on rotation behavior in pre-clinical models. The scientists used a pre-synaptic (before...

  • Therapeutic Pipeline Program, 2013
    Exenatide as a Treatment for Patients with Parkinson’s Disease

    Objective/Rationale:             
    Laboratory data from several teams have indicated potential beneficial effects of the drug Exenatide on the survival of dopamine cells. In a small group of patients...

  • Rapid Response Innovation Awards, 2013
    Effect of Alpha-Synuclein Depletion in Dopamine Neurons of Pre-Clinical Models

    Objective/Rationale:
    A key event in the development of pathological changes in the nervous system of Parkinson’s disease patients is aggregation of a small synaptic protein: alpha-synuclein. Certain...

  • Dyskinesia Challenge, 2013
    5-Hydroxytryptophan and Eltoprazine for the Treatment of Levodopa-Induced Dyskinesia

    Objective/Rationale:             
    The appearance of dyskinesia presents new challenges as a symptom of long-term Parkinson’s therapy with levodopa. Our recent studies have identified the serotonin...

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