The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Pharmacodynamic Biomarkers of LRRK2 Activity, 2010LRRK2 Dimerization as Pharmacodynamic Biomarkers of Activity
Objective/Rationale:
A promising target for neuroprotective therapies in Parkinson’s disease has emerged in the LRRK2 protein kinase. Proteins with similarities to LRRK2 have been successfully... -
Novel Hypotheses in Parkinson's Disease, 2010Quantitative Analysis of S-Nitrosylated Proteins in Parkinson's Disease
Objective/Rationale:
Free radical stress may play a role in pathogenesis of Parkinson’s disease (PD). In this project, we study how free radicals related to reactive nitrogen (N) and oxygen (O)... -
Understanding LRRK2 Biology, 2010Functional Analysis of LRRK2: Focus on Autophagy
Promising Outcomes of Original Grant:
The overall purpose of the original grant was to utilize pre-clinical and human model systems to better understand LRRK biology. The original aims proposed were to... -
Understanding LRRK2 Biology, 2010Biochemical characterization of full length human recombinant LRRK1 and LRRK2
Promising Outcomes of Original Grant:
In our initial application we proposed to take advantage of a lentiviral system recently developed in KULeuven to express full-length, soluble human LRRK1 and... -
MJFF Research Grant, 2010LRRK2 G2019S Disease Penetrance Modifiers
Objective/Rationale:
The most commonly found mutation in Parkinson’s disease patients is LRRK2 G2019S. This mutation can lead to the development of Parkinson’s disease at very different ages, from... -
MJFF Research Grant, 2010Characterization of an Inhibitor Compound of LRRK2 Function
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some...
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Our funding programs support basic, translational and clinical research from academia and industry.