The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2008Evaluation of the striatum-enriched genes, CalDAG-GEF1 and CalDAG-GEF2, as targets for the treatment and prevention of L-DOPA induced dyskinesias
Objective/Rationale:
The most widely prescribed therapy for Parkinson’s disease is levodopa (L-DOPA), which allows patients to regain motor control. However, many patients develop adverse reactions to... -
Target Validation, 2008CaMKII as a Therapeutic Target in Parkinson's Disease
Objective/Rationale:
Neurons in the striatum play a critical role in the fine control of movements. The primary loss of dopamine neurons in Parkinson's Disease induces dramatic secondary changes in the...
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Target Validation, 2008Hsp90 as a Target for Neuroprotective Agents in Parkinson's Disease
Objective/Rationale:
Cell death caused by alpha-synuclein aggregation is thought to play a central role in the pathogenesis of Parkinson’s disease. Previous studies have found that a class of... -
Target Validation, 2008NBD peptides in a pre-clinical model model of Parkinson's disease
Objective/Rationale:
Recently we have demonstrated that NF-kB activation is induced in vivo in the SNpc of Parkinson's disease patients and an MPTP-pre-clinical model, and that selective inhibition of... -
Target Validation, 2008Mu Opioid Receptors as a Drug Target for Treating Motor Fluctuations in PD
Objective/Rationale:
Impaired gastric emptying is commonly found in Parkinson's disease and impacts the effectiveness of oral treatment given to PD patients. Blocking opiate receptors improves the anti...
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Target Validation, 2008Dopaminergic Neuroprotection by Regulator of G-protein Signaling 10 (RGS10)
Objective/Rationale:
Nigral dopamine (DA) neurons are extremely sensitive to inflammatory stimuli; therefore, chronic neuroinflammation has been implicated in the pathogenesis of Parkinson's disease...
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Our funding programs support basic, translational and clinical research from academia and industry.