The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2007Effects of PYM50028 in Reversing Dopaminergic Neuronal Degeneration and Behavioral Impairments in Parkinson's Disease
Objective/Rationale:
The objective of this project is to assess the effects of oral administration of Cogane™ (PYM50028) in reversing the changes in the brain involved in Parkinson’s disease (PD) and... -
Therapeutics Development Initiative, 2007Development of Inhibitors of Alpha-Synuclein Toxicity to Treat Parkinson's Disease
Objective/Rationale:
Many of the symptoms of Parkinson’s disease are caused by the death of dopamine (DA) producing neurons that control movement. Alpha-synuclein is a protein which accumulates in the... -
Therapeutics Development Initiative, 2007NF-kB as target for Parkinson's Disease Therapy
Objective/Rationale:
Chronic inflammation mediated by microglial cells is the fundamental process contributing to the death of dopamine producing neurons in the brain. Production of inflammatory... -
Rapid Response Innovation Awards, 2007Restrain FGF20 by miRNA: Lowering the Risk to Parkinson's Disease
Objective/Rationale:
The variations in FGF20 gene play important roles in developing Parkinson’s disease. Recently, we found such a genetic variation in FGF20 gene strongly associated with PD. That... -
Rapid Response Innovation Awards, 2007Engineered Drug Receptors as a Parkinson's Disease Therapy
Objective/Rationale:
The purpose of this project is to determine whether insertion of an engineered drug receptor into the subthalamic nucleus of a parkinsonian rat can alleviate akinesia when the... -
Rapid Response Innovation Awards, 2007Differentiation of Human Amniotic Fluid Stem Cells for Potential Use in Parkinson's Disease
Objective/Rationale:
Cell replacement remains one of the most promising approaches to treat Parkinson’s, particularly at late stages of the disease. Legal, ethical and pragmatic concerns have become...
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Our funding programs support basic, translational and clinical research from academia and industry.