The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2006Granulocyte-colony Stimulating Factor (G-CSF) as a Neuroprotective Therapy for Parkinson's Disease
Although a relatively large number of drugs is available to alleviate the symptoms of Parkinson's disease, there is no therapy available so far that halts or delays the disease progression. This...
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Target Validation, 2006Cell-specific Lentiviral Vectors to Target and Normalize GAD 67 Expression in enkephalinergic striatal out-put neurons in experimental Parkinson's Disease
In Parkinson's disease, neurons of the striatum become dysregulated. Therefore signals are not processed correctly and as a consequence the symptoms of PD arise. Lentiviral vectors transduce both...
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Target Validation, 2006High-throughput Screen for Small Molecule LRRK2 Inhibitors
The last decade of Parkinson's disease research heralded the discovery of specific genes mutated in rare familial disease cases. Investigating these rare gene mutations has provided a heightened...
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Target Validation, 2006Targeting LRRK2 for Parkinson's Disease
While the causes of Parkinson's disease are not clearly established, information gained from rare genetic mutations has provided insights into basic pathological mechanisms. A common genetic lesion...
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Target Validation, 2006Lentivirally-Delivered GRK2 and GRK6 for Decreasing Severity of Levodopa-induced Dyskinesia
Dopamine receptors are internalized into the cells once stimulated by their agonist in physiological conditions. The applicants have recently shown that, in the context of levodopa-induced dyskinesias...
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Target Validation, 2006Chemical Deorphaning of GPR88: A Candidate Modulator of Motor Function
Dopamine replacement therapy for Parkinson's disease activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a...
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Our funding programs support basic, translational and clinical research from academia and industry.