The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Cell Replacement Therapy, 2004Transplanation of Cell-Derived Dopaminergic Neurons Into the Brains of MPTP-treated Pre-clinical Models
Previous work has identified a stromal cell-derived inducing activity (SDIA) in a stromal cell line (PA6 cells) that can induce mouse and primate ES cells to differentiate into mid/hindbrain neurons...
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Cell Line, 2004Improving the Long-term Survival & Functionality of the Transplanted Human Dopaminergic Neurons Through Space Creation Strategy
The ultimate goal of this study is to enhance the long-term viability and functionality of human embryonic stem (hES) cell-derived dopaminergic (DA) neurons for cell therapy in Parkinson's disease. To...
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Cell Replacement Therapy, 2004Combined Stem Cell Transplant & Growth Factor Therapy for PD
Cell replacement remains a viable option for Parkinson's disease. In the past few years, we and others have succeeded in producing large numbers of dopamine neurons from human embryonic stem cells, a...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Role of Nurr1 in survival, maintenance and function of midbrain dopamine neurons:Implications for disease intervention and therapy for PD
Nurr1 has been discovered as one of the key factors regulating survival and maintenance of midbrain dopamine neurons. Last year, Le and collaborators (Nature Genetics, 3:385, 2003) reported the...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Generation and Characterization of Mice with Inducible and Cell-Type Specific Interruption ofGDNF Signaling
The primary goal of this proposal is the generation of two powerful and innovative conditional mouse knockout strains to interrupt GDNF signaling. We propose to conditionally knock out the GDNF...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Small Molecules That Promote Regeneration of Dopaminergic Neurons from Human Neural Stem Cells
For a better understanding of the signaling pathways that instruct neural precursor cells to differentiate into dopaminergic (DA) neurons (which are lost in the brain of Parkinson's Disease patients)...
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Our funding programs support basic, translational and clinical research from academia and industry.